Gene description for Actc1
Gene name actin, alpha, cardiac muscle 1
Gene symbol Actc1
Other names/aliases Actc-1
Species Mus musculus
 Database cross references - Actc1
ExoCarta ExoCarta_11464
Entrez Gene 11464
UniProt P68033  
 Actc1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Actc1
Molecular Function
    ATPase activity GO:0016887 ISO
    myosin binding GO:0017022 ISO
    nucleotide binding GO:0000166 IEA
    ATP binding GO:0005524 ISO
Biological Process
    negative regulation of apoptotic process GO:0043066 IMP
    skeletal muscle thin filament assembly GO:0030240 IMP
    actin filament-based movement GO:0030048 ISO
    actin-mediated cell contraction GO:0070252 IMP
    cardiac muscle tissue morphogenesis GO:0055008 IMP
    metabolic process GO:0008152 ISO
    cardiac myofibril assembly GO:0055003 IMP
    cardiac muscle contraction GO:0060048 ISO
    actin-myosin filament sliding GO:0033275 ISO
    actomyosin structure organization GO:0031032 IMP
    heart contraction GO:0060047 ISO
Subcellular Localization
    actin filament GO:0005884 ISO
    membrane GO:0016020 ISO
    extracellular exosome GO:0070062 ISO
    extracellular space GO:0005615 ISO
    blood microparticle GO:0072562 ISO
    focal adhesion GO:0005925 ISO
    cytoplasm GO:0005737 ISO
    actomyosin, actin portion GO:0042643 ISO
    sarcomere GO:0030017 ISO
    I band GO:0031674 IDA
    cytoskeleton GO:0005856 IEA
 Experiment description of studies that identified Actc1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Actc1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Actc1 is involved
PathwayEvidenceSource
Striated Muscle Contraction IEA Reactome





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