Gene description for Acvr1
Gene name activin A receptor, type 1
Gene symbol Acvr1
Other names/aliases ALK2
ActR-I
ActRIA
Acvr
Acvrlk2
Alk-2
Alk8
D330013D15Rik
SKR1
Tsk7L
Species Mus musculus
 Database cross references - Acvr1
ExoCarta ExoCarta_11477
Vesiclepedia VP_11477
Entrez Gene 11477
UniProt P37172  
 Acvr1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Acvr1
Molecular Function
    protein kinase activity GO:0004672 ISO
    protein serine/threonine kinase activity GO:0004674 ISO
    transmembrane receptor protein serine/threonine kinase activity GO:0004675 ISO
    transforming growth factor beta receptor activity, type I GO:0005025 IBA
    transforming growth factor beta receptor activity, type I GO:0005025 IDA
    transforming growth factor beta receptor activity, type II GO:0005026 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ATP binding GO:0005524 ISO
    activin receptor activity, type I GO:0016361 IDA
    activin receptor activity, type I GO:0016361 ISO
    activin receptor activity, type I GO:0016361 ISO
    activin receptor activity, type II GO:0016362 IEA
    growth factor binding GO:0019838 IDA
    protein homodimerization activity GO:0042803 IEA
    protein homodimerization activity GO:0042803 ISO
    cadherin binding GO:0045296 IEA
    cadherin binding GO:0045296 ISO
    SMAD binding GO:0046332 IBA
    SMAD binding GO:0046332 IEA
    SMAD binding GO:0046332 ISO
    metal ion binding GO:0046872 IEA
    activin binding GO:0048185 IPI
    activin binding GO:0048185 ISO
    transforming growth factor beta binding GO:0050431 IDA
    transforming growth factor beta binding GO:0050431 ISO
    transforming growth factor beta receptor activity, type III GO:0070123 IEA
    BMP receptor activity GO:0098821 IEA
    BMP receptor activity GO:0098821 ISO
    protein tyrosine kinase binding GO:1990782 IEA
    protein tyrosine kinase binding GO:1990782 ISO
Biological Process
    branching involved in blood vessel morphogenesis GO:0001569 IMP
    urogenital system development GO:0001655 ISO
    in utero embryonic development GO:0001701 IMP
    gastrulation with mouth forming second GO:0001702 IMP
    mesoderm formation GO:0001707 IMP
    neural crest cell migration GO:0001755 IMP
    acute inflammatory response GO:0002526 IEP
    embryonic heart tube morphogenesis GO:0003143 IEA
    embryonic heart tube morphogenesis GO:0003143 ISO
    outflow tract septum morphogenesis GO:0003148 IMP
    atrioventricular valve morphogenesis GO:0003181 IMP
    mitral valve morphogenesis GO:0003183 IEA
    mitral valve morphogenesis GO:0003183 ISO
    endocardial cushion formation GO:0003272 IMP
    endocardial cushion fusion GO:0003274 IMP
    atrial septum primum morphogenesis GO:0003289 IMP
    atrial septum primum morphogenesis GO:0003289 ISO
    transforming growth factor beta receptor signaling pathway GO:0007179 IBA
    transforming growth factor beta receptor signaling pathway GO:0007179 IDA
    transforming growth factor beta receptor signaling pathway GO:0007179 ISO
    transforming growth factor beta receptor signaling pathway GO:0007179 TAS
    germ cell development GO:0007281 IMP
    determination of left/right symmetry GO:0007368 IMP
    gastrulation GO:0007369 IMP
    mesoderm development GO:0007498 IMP
    heart development GO:0007507 IBA
    heart development GO:0007507 IMP
    embryo development GO:0009790 IMP
    dorsal/ventral pattern formation GO:0009953 IBA
    negative regulation of signal transduction GO:0009968 ISO
    cell differentiation GO:0030154 IBA
    regulation of ossification GO:0030278 ISO
    positive regulation of cell migration GO:0030335 IEA
    positive regulation of cell migration GO:0030335 ISO
    positive regulation of bone mineralization GO:0030501 IEA
    positive regulation of bone mineralization GO:0030501 ISO
    BMP signaling pathway GO:0030509 IBA
    BMP signaling pathway GO:0030509 IMP
    BMP signaling pathway GO:0030509 ISO
    activin receptor signaling pathway GO:0032924 IEA
    activin receptor signaling pathway GO:0032924 ISO
    negative regulation of activin receptor signaling pathway GO:0032926 IEA
    negative regulation of activin receptor signaling pathway GO:0032926 ISO
    positive regulation of osteoblast differentiation GO:0045669 IEA
    positive regulation of osteoblast differentiation GO:0045669 ISO
    positive regulation of DNA-templated transcription GO:0045893 ISO
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO
    smooth muscle cell differentiation GO:0051145 IMP
    pharyngeal system development GO:0060037 IMP
    positive regulation of SMAD protein signal transduction GO:0060391 IMP
    positive regulation of SMAD protein signal transduction GO:0060391 ISO
    ventricular septum morphogenesis GO:0060412 IMP
    cardiac muscle cell fate commitment GO:0060923 IEA
    cardiac muscle cell fate commitment GO:0060923 ISO
    endocardial cushion cell fate commitment GO:0061445 IEA
    endocardial cushion cell fate commitment GO:0061445 ISO
    positive regulation of cardiac epithelial to mesenchymal transition GO:0062043 IMP
    cellular response to growth factor stimulus GO:0071363 IBA
    cellular response to BMP stimulus GO:0071773 ISO
    positive regulation of determination of dorsal identity GO:2000017 IEA
    positive regulation of determination of dorsal identity GO:2000017 ISO
    negative regulation of G1/S transition of mitotic cell cycle GO:2000134 IEA
    negative regulation of G1/S transition of mitotic cell cycle GO:2000134 ISO
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IEA
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 ISO
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    apical part of cell GO:0045177 IDA
    activin receptor complex GO:0048179 IEA
    activin receptor complex GO:0048179 ISO
    BMP receptor complex GO:0070724 IBA
 Experiment description of studies that identified Acvr1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Acvr1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Smad7  
Affinity Capture-Western Mus musculus
2 Smad6  
Affinity Capture-Western Mus musculus
View the network image/svg+xml
 Pathways in which Acvr1 is involved
No pathways found





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