Gene description for Acvr1
Gene name activin A receptor, type 1
Gene symbol Acvr1
Other names/aliases ALK2
ActR-I
ActRIA
Acvr
Acvrlk2
Alk-2
Alk8
D330013D15Rik
SKR1
Tsk7L
Species Mus musculus
 Database cross references - Acvr1
ExoCarta ExoCarta_11477
Entrez Gene 11477
UniProt P37172  
 Acvr1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Acvr1
Molecular Function
    receptor signaling protein serine/threonine kinase activity GO:0004702 ISO
    transmembrane receptor protein serine/threonine kinase activity GO:0004675 IEA
    activin receptor activity, type I GO:0016361 ISO
    protein homodimerization activity GO:0042803 ISO
    transforming growth factor beta receptor activity, type I GO:0005025 IDA
    growth factor binding GO:0019838 IDA
    kinase activity GO:0016301 IEA
    transforming growth factor beta binding GO:0050431 ISO
    ATP binding GO:0005524 ISO
    protein serine/threonine kinase activity GO:0004674 ISO
    nucleotide binding GO:0000166 IEA
    transferase activity GO:0016740 IEA
    SMAD binding GO:0046332 ISO
    metal ion binding GO:0046872 IEA
    protein kinase activity GO:0004672 ISO
    activin binding GO:0048185 ISO
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
Biological Process
    atrial septum primum morphogenesis GO:0003289 ISO
    BMP signaling pathway GO:0030509 ISO
    pathway-restricted SMAD protein phosphorylation GO:0060389 ISO
    mesoderm formation GO:0001707 IMP
    mitral valve morphogenesis GO:0003183 ISO
    heart development GO:0007507 IMP
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 ISO
    activin receptor signaling pathway GO:0032924 ISO
    positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 ISO
    negative regulation of signal transduction GO:0009968 ISO
    regulation of ossification GO:0030278 ISO
    embryonic heart tube morphogenesis GO:0003143 ISO
    transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 IEA
    smooth muscle cell differentiation GO:0051145 IMP
    intracellular signal transduction GO:0035556 ISO
    urogenital system development GO:0001655 ISO
    mesoderm development GO:0007498 IMP
    positive regulation of osteoblast differentiation GO:0045669 ISO
    positive regulation of determination of dorsal identity GO:2000017 ISO
    determination of left/right symmetry GO:0007368 IMP
    neural crest cell migration GO:0001755 IMP
    pharyngeal system development GO:0060037 IMP
    negative regulation of activin receptor signaling pathway GO:0032926 ISO
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    positive regulation of bone mineralization GO:0030501 ISO
    germ cell development GO:0007281 IMP
    transforming growth factor beta receptor signaling pathway GO:0007179 TAS
    gastrulation GO:0007369 IMP
    peptidyl-threonine phosphorylation GO:0018107 ISO
    embryo development GO:0009790 IMP
    cardiac muscle cell fate commitment GO:0060923 ISO
    signal transduction by protein phosphorylation GO:0023014 ISO
    phosphorylation GO:0016310 IEA
    in utero embryonic development GO:0001701 IMP
    endocardial cushion cell fate commitment GO:0061445 ISO
    patterning of blood vessels GO:0001569 IMP
    protein phosphorylation GO:0006468 ISO
    positive regulation of transcription, DNA-templated GO:0045893 ISO
    gastrulation with mouth forming second GO:0001702 IMP
    G1/S transition of mitotic cell cycle GO:0000082 ISO
Subcellular Localization
    membrane GO:0016020 IEA
    integral component of membrane GO:0016021 IEA
    apical part of cell GO:0045177 IDA
    activin receptor complex GO:0048179 ISO
    integral component of plasma membrane GO:0005887 ISO
 Experiment description of studies that identified Acvr1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Acvr1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Acvr1 is involved
No pathways found





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