Gene description for Adam9
Gene name a disintegrin and metallopeptidase domain 9 (meltrin gamma)
Gene symbol Adam9
Other names/aliases AU020942
MDC9
Mltng
mKIAA0021
Species Mus musculus
 Database cross references - Adam9
ExoCarta ExoCarta_11502
Vesiclepedia VP_11502
Entrez Gene 11502
UniProt Q61072  
 Adam9 identified in sEVs derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Adam9
Molecular Function
    metalloendopeptidase activity GO:0004222 IBA
    metalloendopeptidase activity GO:0004222 IDA
    metalloendopeptidase activity GO:0004222 ISO
    protein kinase C binding GO:0005080 IPI
    integrin binding GO:0005178 IBA
    integrin binding GO:0005178 ISO
    protein binding GO:0005515 IPI
    collagen binding GO:0005518 ISO
    metallopeptidase activity GO:0008237 ISO
    SH3 domain binding GO:0017124 IDA
    SH3 domain binding GO:0017124 ISO
    laminin binding GO:0043236 ISO
    metal ion binding GO:0046872 IEA
    metalloendopeptidase activity involved in amyloid precursor protein catabolic process GO:1902945 ISO
Biological Process
    membrane protein ectodomain proteolysis GO:0006509 IBA
    membrane protein ectodomain proteolysis GO:0006509 IDA
    membrane protein ectodomain proteolysis GO:0006509 ISO
    membrane protein ectodomain proteolysis GO:0006509 ISO
    cell adhesion GO:0007155 ISO
    cell-matrix adhesion GO:0007160 ISO
    transforming growth factor beta receptor signaling pathway GO:0007179 IBA
    transforming growth factor beta receptor signaling pathway GO:0007179 IMP
    transforming growth factor beta receptor signaling pathway GO:0007179 ISO
    response to manganese ion GO:0010042 ISO
    cell migration GO:0016477 IDA
    protein processing GO:0016485 ISO
    positive regulation of cell migration GO:0030335 ISO
    membrane protein intracellular domain proteolysis GO:0031293 ISO
    cell adhesion mediated by integrin GO:0033627 IDA
    cell adhesion mediated by integrin GO:0033627 ISO
    positive regulation of cell adhesion mediated by integrin GO:0033630 ISO
    cell-cell adhesion mediated by integrin GO:0033631 IBA
    positive regulation of macrophage fusion GO:0034241 ISO
    response to tumor necrosis factor GO:0034612 ISO
    monocyte activation GO:0042117 ISO
    response to hydrogen peroxide GO:0042542 ISO
    amyloid precursor protein catabolic process GO:0042987 ISO
    positive regulation of MAP kinase activity GO:0043406 ISO
    positive regulation of protein secretion GO:0050714 ISO
    positive regulation of membrane protein ectodomain proteolysis GO:0051044 IDA
    response to glucocorticoid GO:0051384 IMP
    positive regulation of keratinocyte migration GO:0051549 ISO
    response to calcium ion GO:0051592 ISO
    cellular response to lipopolysaccharide GO:0071222 ISO
Subcellular Localization
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IMP
    extracellular space GO:0005615 ISO
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    external side of plasma membrane GO:0009897 IDA
    cell surface GO:0009986 IDA
    cell surface GO:0009986 ISO
    basolateral plasma membrane GO:0016323 ISO
 Experiment description of studies that identified Adam9 in sEVs
1
Experiment ID 214
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Adam9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Syngap1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
2 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Adam9 is involved
No pathways found





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