Gene description for Avil
Gene name advillin
Gene symbol Avil
Other names/aliases Advil
DOC6
Species Mus musculus
 Database cross references - Avil
ExoCarta ExoCarta_11567
Vesiclepedia VP_11567
Entrez Gene 11567
UniProt O88398  
 Avil identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Avil
Molecular Function
    actin binding GO:0003779 ISO
    actin binding GO:0003779 ISS
    protein binding GO:0005515 IPI
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IBA
    actin filament binding GO:0051015 IBA
    actin filament binding GO:0051015 ISO
    actin filament binding GO:0051015 ISS
    Arp2/3 complex binding GO:0071933 ISO
    Arp2/3 complex binding GO:0071933 ISS
Biological Process
    actin filament organization GO:0007015 ISO
    actin filament organization GO:0007015 ISS
    actin filament organization GO:0007015 ISS
    nervous system development GO:0007399 IEA
    nervous system development GO:0007399 ISO
    actin polymerization or depolymerization GO:0008154 IBA
    positive regulation of lamellipodium assembly GO:0010592 ISO
    positive regulation of lamellipodium assembly GO:0010592 ISS
    positive regulation of neuron projection development GO:0010976 IDA
    positive regulation of neuron projection development GO:0010976 ISO
    actin filament severing GO:0051014 IBA
    barbed-end actin filament capping GO:0051016 IBA
    actin filament capping GO:0051693 IEA
    cilium assembly GO:0060271 ISO
    cilium assembly GO:0060271 ISS
    regulation of diacylglycerol biosynthetic process GO:1900480 ISO
    regulation of diacylglycerol biosynthetic process GO:1900480 ISS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IEA
    actin filament GO:0005884 ISO
    actin filament GO:0005884 ISS
    focal adhesion GO:0005925 ISO
    focal adhesion GO:0005925 ISS
    actin cytoskeleton GO:0015629 IBA
    lamellipodium GO:0030027 ISO
    lamellipodium GO:0030027 ISS
    axon GO:0030424 IEA
    cell projection GO:0042995 ISO
    cell projection GO:0042995 ISS
    neuron projection GO:0043005 ISO
    neuron projection GO:0043005 ISS
 Experiment description of studies that identified Avil in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Avil
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Svil  
Co-fractionation Mus musculus
2 Crk 12928
Affinity Capture-MS Mus musculus
3 Fancd2  
Affinity Capture-MS Mus musculus
4 Vil1  
Co-fractionation Mus musculus
5 Scarf1  
Affinity Capture-Western Mus musculus
View the network image/svg+xml
 Pathways in which Avil is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here