Gene description for Aebp1
Gene name AE binding protein 1
Gene symbol Aebp1
Other names/aliases ACLP
Species Mus musculus
 Database cross references - Aebp1
ExoCarta ExoCarta_11568
Vesiclepedia VP_11568
Entrez Gene 11568
UniProt Q640N1  
 Aebp1 identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Aebp1
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IBA
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IDA
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 ISO
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IBA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IEA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 ISO
    carboxypeptidase activity GO:0004180 IDA
    metallocarboxypeptidase activity GO:0004181 IBA
    metallocarboxypeptidase activity GO:0004181 IEA
    calmodulin binding GO:0005516 IEA
    collagen binding GO:0005518 ISO
    collagen binding GO:0005518 ISS
    zinc ion binding GO:0008270 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    regulation of DNA-templated transcription GO:0006355 IBA
    regulation of DNA-templated transcription GO:0006355 IDA
    proteolysis GO:0006508 IEA
    peptide metabolic process GO:0006518 IBA
    protein processing GO:0016485 IBA
    regulation of collagen fibril organization GO:1904026 ISO
    regulation of collagen fibril organization GO:1904026 ISS
Subcellular Localization
    extracellular space GO:0005615 HDA
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified Aebp1 in sEVs
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Aebp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Nfe2  
Two-hybrid Mus musculus
2 Atg5  
Affinity Capture-RNA Mus musculus
3 Gmeb2  
Two-hybrid Mus musculus
View the network image/svg+xml
 Pathways in which Aebp1 is involved
No pathways found





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