Gene description for Aebp2
Gene name AE binding protein 2
Gene symbol Aebp2
Other names/aliases AU023766
B230313N05Rik
Species Mus musculus
 Database cross references - Aebp2
ExoCarta ExoCarta_11569
Entrez Gene 11569
UniProt Q9Z248  
 Aebp2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Aebp2
Molecular Function
    DNA binding GO:0003677 IDA
    nucleic acid binding GO:0003676 IEA
    metal ion binding GO:0046872 IEA
    transcription corepressor activity GO:0003714 IMP
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001078 IMP
Biological Process
    transcription from RNA polymerase II promoter GO:0006366 IMP
    transcription, DNA-templated GO:0006351 IEA
    regulation of transcription, DNA-templated GO:0006355 IDA
    chromatin modification GO:0016568 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP
Subcellular Localization
    ESC/E(Z) complex GO:0035098 ISO
    nucleus GO:0005634 IDA
 Experiment description of studies that identified Aebp2 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Aebp2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Aebp2 is involved
PathwayEvidenceSource
PKMTs methylate histone lysines IEA Reactome
PRC2 methylates histones and DNA IEA Reactome





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