Gene description for Angpt1
Gene name	angiopoietin 1
Gene symbol	Angpt1
Other names/aliases	1110046O21Rik Ang-1 Ang1
Species	Mus musculus
Database cross references - Angpt1
ExoCarta	ExoCarta_11600
Vesiclepedia	VP_11600
Entrez Gene	11600
UniProt	O08538
Angpt1 identified in sEVs derived from the following tissue/cell type
Fibroblasts	23260141

Gene ontology annotations for Angpt1

Molecular Function     signaling receptor binding GO:0005102 IPI     vascular endothelial growth factor receptor binding GO:0005172 TAS     protein binding GO:0005515 IPI     receptor tyrosine kinase binding GO:0030971 IBA     receptor tyrosine kinase binding GO:0030971 IEA     receptor tyrosine kinase binding GO:0030971 ISO     identical protein binding GO:0042802 IEA     identical protein binding GO:0042802 ISO     receptor ligand activity GO:0048018 IEA Biological Process     angiogenesis GO:0001525 IBA     angiogenesis GO:0001525 IDA     angiogenesis GO:0001525 IMP     ovarian follicle development GO:0001541 ISO     branching involved in blood vessel morphogenesis GO:0001569 TAS     vasculogenesis GO:0001570 TAS     in utero embryonic development GO:0001701 IGI     in utero embryonic development GO:0001701 IMP     negative regulation of protein phosphorylation GO:0001933 IDA     positive regulation of protein phosphorylation GO:0001934 ISO     sprouting angiogenesis GO:0002040 IEA     sprouting angiogenesis GO:0002040 ISO     positive regulation of receptor internalization GO:0002092 IEA     positive regulation of receptor internalization GO:0002092 ISO     negative regulation of cytokine production involved in immune response GO:0002719 IDA     endocardium morphogenesis GO:0003160 TAS     negative regulation of cell adhesion GO:0007162 IEA     negative regulation of cell adhesion GO:0007162 ISO     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IDA     activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 ISO     endoderm development GO:0007492 TAS     blood coagulation GO:0007596 IEA     positive regulation of endothelial cell migration GO:0010595 ISO     positive regulation of endothelial cell migration GO:0010595 TAS     positive regulation of gene expression GO:0010628 IEA     positive regulation of gene expression GO:0010628 ISO     regulation of skeletal muscle satellite cell proliferation GO:0014842 IEA     regulation of skeletal muscle satellite cell proliferation GO:0014842 ISO     hemopoiesis GO:0030097 IDA     heparin biosynthetic process GO:0030210 IEA     heparin biosynthetic process GO:0030210 ISO     positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 TAS     positive regulation of protein ubiquitination GO:0031398 IEA     positive regulation of protein ubiquitination GO:0031398 ISO     cell-substrate adhesion GO:0031589 IDA     regulation of tumor necrosis factor production GO:0032680 IDA     positive regulation of peptidyl-serine phosphorylation GO:0033138 IDA     protein localization to cell surface GO:0034394 IEA     protein localization to cell surface GO:0034394 ISO     negative regulation of protein import into nucleus GO:0042308 IDA     negative regulation of apoptotic process GO:0043066 ISO     negative regulation of vascular permeability GO:0043116 IDA     negative regulation of vascular permeability GO:0043116 ISO     regulation of canonical NF-kappaB signal transduction GO:0043122 IGI     regulation of protein binding GO:0043393 IDA     negative regulation of neuron apoptotic process GO:0043524 IDA     negative regulation of neuron apoptotic process GO:0043524 IGI     positive regulation of blood vessel endothelial cell migration GO:0043536 IEA     positive regulation of blood vessel endothelial cell migration GO:0043536 ISO     positive regulation of cell adhesion GO:0045785 IDA     Tie signaling pathway GO:0048014 IBA     Tie signaling pathway GO:0048014 ISO     Tie signaling pathway GO:0048014 TAS     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO     positive regulation of coagulation GO:0050820 IEA     positive chemotaxis GO:0050918 IEA     positive chemotaxis GO:0050918 ISO     neuron apoptotic process GO:0051402 IDA     neuron apoptotic process GO:0051402 IGI     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IDA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO     cardiac muscle tissue morphogenesis GO:0055008 TAS     vasculogenesis involved in coronary vascular morphogenesis GO:0060979 TAS     positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     glomerulus vasculature development GO:0072012 IDA     glomerulus vasculature development GO:0072012 ISO     positive regulation of blood-brain barrier permeability GO:1905605 IEA     positive regulation of blood-brain barrier permeability GO:1905605 ISO     negative regulation of endothelial cell apoptotic process GO:2000352 IEA     negative regulation of endothelial cell apoptotic process GO:2000352 ISO     regulation of macrophage migration inhibitory factor signaling pathway GO:2000446 IDA Subcellular Localization     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IEA     extracellular space GO:0005615 ISO     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     microvillus GO:0005902 IEA     microvillus GO:0005902 ISO     membrane raft GO:0045121 IEA     membrane raft GO:0045121 ISO     collagen-containing extracellular matrix GO:0062023 IBA