Gene description for Angpt1
Gene name angiopoietin 1
Gene symbol Angpt1
Other names/aliases 1110046O21Rik
Species Mus musculus
 Database cross references - Angpt1
ExoCarta ExoCarta_11600
Entrez Gene 11600
UniProt O08538  
 Angpt1 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Angpt1
Molecular Function
    receptor tyrosine kinase binding GO:0030971 ISO
    vascular endothelial growth factor receptor binding GO:0005172 TAS
    receptor binding GO:0005102 IPI
Biological Process
    Tie signaling pathway GO:0048014 TAS
    multicellular organismal development GO:0007275 IEA
    negative regulation of protein import into nucleus GO:0042308 IDA
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IDA
    vasculogenesis GO:0001570 TAS
    positive regulation of peptidyl-serine phosphorylation GO:0033138 IDA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO
    positive regulation of endothelial cell migration GO:0010595 TAS
    positive regulation of cell adhesion GO:0045785 IDA
    cell-substrate adhesion GO:0031589 IDA
    protein homooligomerization GO:0051260 ISO
    positive chemotaxis GO:0050918 ISO
    in utero embryonic development GO:0001701 IMP
    positive regulation of protein ubiquitination GO:0031398 ISO
    positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 TAS
    vasculogenesis involved in coronary vascular morphogenesis GO:0060979 TAS
    negative regulation of protein phosphorylation GO:0001933 IDA
    negative regulation of cytokine secretion involved in immune response GO:0002740 IDA
    regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 IGI
    positive regulation of blood vessel endothelial cell migration GO:0043536 ISO
    negative regulation of apoptotic process GO:0043066 ISO
    endoderm development GO:0007492 TAS
    activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 ISO
    regulation of tumor necrosis factor production GO:0032680 IDA
    positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 IDA
    negative regulation of cell adhesion GO:0007162 ISO
    positive regulation of protein kinase B signaling GO:0051897 ISO
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO
    cell differentiation GO:0030154 IEA
    heparin biosynthetic process GO:0030210 ISO
    patterning of blood vessels GO:0001569 TAS
    endocardium morphogenesis GO:0003160 TAS
    cardiac muscle tissue morphogenesis GO:0055008 TAS
    negative regulation of neuron apoptotic process GO:0043524 IGI
    ovarian follicle development GO:0001541 ISO
    glomerulus vasculature development GO:0072012 ISO
    angiogenesis GO:0001525 IMP
    hemopoiesis GO:0030097 IDA
    regulation of satellite cell proliferation GO:0014842 ISO
    sprouting angiogenesis GO:0002040 ISO
    positive regulation of receptor internalization GO:0002092 ISO
    regulation of protein binding GO:0043393 IDA
    regulation of macrophage migration inhibitory factor signaling pathway GO:2000446 IDA
    negative regulation of vascular permeability GO:0043116 ISO
    negative regulation of endothelial cell apoptotic process GO:2000352 ISO
    protein localization to cell surface GO:0034394 ISO
Subcellular Localization
    membrane raft GO:0045121 ISO
    extracellular region GO:0005576 IEA
    microvillus GO:0005902 ISO
    plasma membrane GO:0005886 ISO
    extracellular space GO:0005615 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Angpt1 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Angpt1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Angpt1 is involved
Tie2 Signaling IEA Reactome

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