Gene description for Agrn
Gene name agrin
Gene symbol Agrn
Other names/aliases Agrin
Species Mus musculus
 Database cross references - Agrn
ExoCarta ExoCarta_11603
Entrez Gene 11603
 Agrn identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Agrn
Molecular Function
    heparan sulfate proteoglycan binding GO:0043395 IDA
    BMP binding GO:0036122 ISO
    calcium ion binding GO:0005509 ISO
    transforming growth factor beta binding GO:0050431 ISO
    ion channel binding GO:0044325 IPI
    ATPase inhibitor activity GO:0042030 IDA
    protein binding GO:0005515 IPI
    acetylcholine receptor regulator activity GO:0030548 IDA
    dystroglycan binding GO:0002162 ISO
    chondroitin sulfate binding GO:0035374 IDA
Biological Process
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    negative regulation of sodium:potassium-exchanging ATPase activity GO:1903407 IDA
    synapse assembly GO:0007416 ISO
    positive regulation of protein tyrosine kinase activity GO:0061098 IDA
    skeletal muscle acetylcholine-gated channel clustering GO:0071340 ISO
    plasma membrane organization GO:0007009 IMP
    regulation of axon guidance GO:1902667 ISO
    synaptic transmission GO:0007268 ISO
    receptor clustering GO:0043113 ISO
    regulation of cardiac muscle cell membrane potential GO:0086036 IDA
    positive regulation of GTPase activity GO:0043547 ISO
    positive regulation of neuron apoptotic process GO:0043525 IMP
    neuromuscular junction development GO:0007528 IGI
    positive regulation of filopodium assembly GO:0051491 ISO
    regulation of receptor activity GO:0010469 IDA
    regulation of GTPase activity GO:0043087 IDA
    regulation of protein phosphorylation GO:0001932 ISO
    negative regulation of sodium ion export from cell GO:1903277 IDA
    regulation of cardiac muscle contraction GO:0055117 IDA
    positive regulation of synaptic growth at neuromuscular junction GO:0045887 IMP
    regulation of microtubule cytoskeleton organization GO:0070507 ISO
    neurotransmitter receptor metabolic process GO:0045213 IDA
    regulation of synaptic growth at neuromuscular junction GO:0008582 IMP
    positive regulation of protein binding GO:0032092 IDA
    positive regulation of protein phosphorylation GO:0001934 ISO
    multicellular organismal development GO:0007275 IEA
    protein heterotetramerization GO:0051290 ISO
    positive regulation of protein geranylgeranylation GO:2000541 IMP
    cell differentiation GO:0030154 IEA
Subcellular Localization
    sarcolemma GO:0042383 IDA
    integral component of membrane GO:0016021 IEA
    cell surface GO:0009986 IDA
    basal lamina GO:0005605 ISO
    extracellular matrix GO:0031012 ISO
    axonal growth cone GO:0044295 ISO
    cell junction GO:0030054 IEA
    extracellular exosome GO:0070062 ISO
    membrane GO:0016020 IEA
    basement membrane GO:0005604 ISO
    plasma membrane GO:0005886 ISO
    cytoplasm GO:0005737 ISO
    extracellular space GO:0005615 TAS
    synapse GO:0045202 ISO
 Experiment description of studies that identified Agrn in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Agrn
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Agrn is involved
No pathways found

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