Gene description for Ahsg
Gene name alpha-2-HS-glycoprotein
Gene symbol Ahsg
Other names/aliases -
Species Mus musculus
 Database cross references - Ahsg
ExoCarta ExoCarta_11625
Vesiclepedia VP_11625
Entrez Gene 11625
UniProt P29699  
 Ahsg identified in sEVs derived from the following tissue/cell type
Faeces 33431899    
Faeces 33431899    
 Gene ontology annotations for Ahsg
Molecular Function
    endopeptidase inhibitor activity GO:0004866 IBA
    cysteine-type endopeptidase inhibitor activity GO:0004869 IEA
    receptor signaling protein tyrosine kinase inhibitor activity GO:0030294 ISO
Biological Process
    ossification GO:0001503 IDA
    acute-phase response GO:0006953 IBA
    acute-phase response GO:0006953 ISO
    acute-phase response GO:0006953 ISS
    male gonad development GO:0008584 ISO
    negative regulation of cell growth GO:0030308 ISO
    negative regulation of bone mineralization GO:0030502 IBA
    negative regulation of bone mineralization GO:0030502 IDA
    negative regulation of bone mineralization GO:0030502 ISO
    positive regulation of bone resorption GO:0045780 ISO
    negative regulation of insulin receptor signaling pathway GO:0046627 ISO
    regulation of inflammatory response GO:0050727 IBA
    regulation of inflammatory response GO:0050727 ISO
    regulation of inflammatory response GO:0050727 ISS
    positive regulation of phagocytosis GO:0050766 ISO
    positive regulation of phagocytosis GO:0050766 ISS
    protein-containing complex assembly GO:0065003 ISO
Subcellular Localization
    extracellular region GO:0005576 IBA
    extracellular space GO:0005615 IEA
    extracellular space GO:0005615 ISO
    Golgi apparatus GO:0005794 IEA
    Golgi apparatus GO:0005794 ISO
    extracellular matrix GO:0031012 IBA
    protein-containing complex GO:0032991 ISO
    collagen-containing extracellular matrix GO:0062023 ISO
 Experiment description of studies that identified Ahsg in sEVs
1
Experiment ID 303
MISEV standards
EM
Biophysical techniques
Cd63|Cd81|Cd9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33431899    
Organism Mus musculus
Experiment description High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors "Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."
Journal name Nat Commun
Publication year 2021
Sample Faeces
Sample name Intestinal epithelial cells - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Lipid
miRNA
Methods used in the study Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC
2
Experiment ID 304
MISEV standards
EM
Biophysical techniques
Cd63|Cd81|Cd9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33431899    
Organism Mus musculus
Experiment description High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors "Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."
Journal name Nat Commun
Publication year 2021
Sample Faeces
Sample name Intestinal epithelial cells - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Lipid
miRNA
Methods used in the study Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC
 Protein-protein interactions for Ahsg
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fancd2  
Affinity Capture-MS Mus musculus
2 Kcnma1  
Affinity Capture-MS Mus musculus
View the network image/svg+xml



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