Gene description for Sacm1l
Gene name SAC1 suppressor of actin mutations 1-like (yeast)
Gene symbol Sacm1l
Other names/aliases Sac1
Species Rattus norvegicus
 Database cross references - Sacm1l
ExoCarta ExoCarta_116482
Entrez Gene 116482
UniProt Q9ES21  
 Sacm1l identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Sacm1l
Molecular Function
    phosphatidylinositol-3-phosphatase activity GO:0004438 IDA
    phosphatidylinositol bisphosphate phosphatase activity GO:0034593 IDA
    phosphatase activity GO:0016791 IMP
    phosphatidylinositol-4-phosphate phosphatase activity GO:0043812 IDA
Biological Process
    phosphatidylinositol dephosphorylation GO:0046856 IDA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IDA
    Golgi apparatus GO:0005794 ISO
    alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex GO:0032281 ISO
    integral component of endoplasmic reticulum membrane GO:0030176 IDA
 Experiment description of studies that identified Sacm1l in exosomes
1
Experiment ID 225
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Sacm1l
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Sacm1l is involved
PathwayEvidenceSource
Synthesis of PIPs at the ER membrane IEA Reactome
Synthesis of PIPs at the Golgi membrane IEA Reactome





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