Gene description for Txn1
Gene name thioredoxin 1
Gene symbol Txn1
Other names/aliases Txn
Species Rattus norvegicus
 Database cross references - Txn1
ExoCarta ExoCarta_116484
Entrez Gene 116484
UniProt P11232  
 Txn1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
Urine 20535238    
 Gene ontology annotations for Txn1
Molecular Function
    enzyme binding GO:0019899 IPI
    protein disulfide oxidoreductase activity GO:0015035 IEA
    peptide disulfide oxidoreductase activity GO:0015037 ISO
    poly(A) RNA binding GO:0044822 ISO
    thioredoxin-disulfide reductase activity GO:0004791 TAS
    oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor GO:0016671 IBA
Biological Process
    response to thyroxine GO:0097068 IEP
    response to activity GO:0014823 IEP
    glycerol ether metabolic process GO:0006662 IEA
    response to drug GO:0042493 IEP
    negative regulation of hydrogen peroxide-induced cell death GO:1903206 ISO
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    sulfate assimilation GO:0000103 IBA
    cellular response to hyperoxia GO:0071455 IEP
    transcription, DNA-templated GO:0006351 IEA
    response to selenium ion GO:0010269 IEP
    negative regulation of protein export from nucleus GO:0046826 ISO
    regulation of protein import into nucleus, translocation GO:0033158 ISS
    response to dexamethasone GO:0071548 IEP
    response to axon injury GO:0048678 IEP
    cellular response to antibiotic GO:0071236 IEP
    regulation of transcription, DNA-templated GO:0006355 IEA
    positive regulation of peptidyl-serine phosphorylation GO:0033138 ISO
    positive regulation of DNA binding GO:0043388 ISS
    oxidation-reduction process GO:0055114 ISS
    response to radiation GO:0009314 ISS
    cellular response to drug GO:0035690 IEP
    protein folding GO:0006457 IBA
    cellular response to glucose stimulus GO:0071333 IEP
    cellular response to oxidative stress GO:0034599 IBA
    cell redox homeostasis GO:0045454 ISO
Subcellular Localization
    mitochondrion GO:0005739 ISO
    cytosol GO:0005829 ISO
    extracellular region GO:0005576 IEA
    cytoplasm GO:0005737 ISO
    extracellular exosome GO:0070062 ISO
    nucleus GO:0005634 ISO
    axon GO:0030424 IDA
    neuronal cell body GO:0043025 IDA
    dendrite GO:0030425 IDA
 Experiment description of studies that identified Txn1 in exosomes
1
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 98
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
4
Experiment ID 192
ISEV standards
CEM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
CD63|CD81|FLOT
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Txn1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Txn1 is involved
No pathways found





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