Gene description for Tgfbi
Gene name transforming growth factor, beta induced
Gene symbol Tgfbi
Other names/aliases BIGH3
Big-h3
Species Rattus norvegicus
 Database cross references - Tgfbi
ExoCarta ExoCarta_116487
Entrez Gene 116487
 Tgfbi identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Tgfbi
Molecular Function
    collagen binding GO:0005518 ISO
    molecular_function GO:0003674 ND
    cell adhesion molecule binding GO:0050839 IBA
    extracellular matrix binding GO:0050840 ISO
Biological Process
    chondrocyte differentiation GO:0002062 IEP
    extracellular matrix organization GO:0030198 ISO
    cell adhesion GO:0007155 ISO
    angiogenesis GO:0001525 ISO
Subcellular Localization
    proteinaceous extracellular matrix GO:0005578 TAS
    extracellular space GO:0005615 ISO
    trans-Golgi network GO:0005802 ISO
    extracellular exosome GO:0070062 ISO
    basement membrane GO:0005604 IDA
    extracellular matrix GO:0031012 ISO
 Experiment description of studies that identified Tgfbi in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Tgfbi
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tgfbi is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here