Gene description for Ralb
Gene name v-ral simian leukemia viral oncogene homolog B
Gene symbol Ralb
Other names/aliases dRalb
Species Rattus norvegicus
 Database cross references - Ralb
ExoCarta ExoCarta_116546
Vesiclepedia VP_116546
Entrez Gene 116546
UniProt P36860  
 Ralb identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Ralb
Molecular Function
    GTPase activity GO:0003924 IBA
    GTPase activity GO:0003924 ISO
    GTPase activity GO:0003924 ISS
    G protein activity GO:0003925 IEA
    GTP binding GO:0005525 IBA
    GTP binding GO:0005525 IEA
    GTP binding GO:0005525 ISO
    GTP binding GO:0005525 ISS
    GTP binding GO:0005525 NAS
    GDP binding GO:0019003 IBA
    GDP binding GO:0019003 IEA
    GDP binding GO:0019003 ISO
    ubiquitin protein ligase binding GO:0031625 IEA
    ubiquitin protein ligase binding GO:0031625 ISO
    ATPase binding GO:0051117 IEA
    ATPase binding GO:0051117 ISO
Biological Process
    regulation of exocyst assembly GO:0001928 IDA
    positive regulation of protein phosphorylation GO:0001934 ISO
    apoptotic process GO:0006915 IEA
    signal transduction GO:0007165 IEA
    Ras protein signal transduction GO:0007265 IBA
    cellular response to starvation GO:0009267 IEA
    cellular response to starvation GO:0009267 ISO
    receptor internalization GO:0031623 IEA
    receptor internalization GO:0031623 ISO
    positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 IEA
    positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 ISO
    cell division GO:0051301 IEA
    regulation of exocyst localization GO:0060178 IDA
    cellular response to exogenous dsRNA GO:0071360 IEA
    cellular response to exogenous dsRNA GO:0071360 ISO
    positive regulation of protein serine/threonine kinase activity GO:0071902 ISO
    positive regulation of autophagosome assembly GO:2000786 IEA
    positive regulation of autophagosome assembly GO:2000786 ISO
Subcellular Localization
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    midbody GO:0030496 IEA
    midbody GO:0030496 ISO
    midbody GO:0030496 ISS
 Experiment description of studies that identified Ralb in exosomes
1
Experiment ID 192
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|HSP70|CD63|CD81|FLOT
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M."
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Ralb
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ralb is involved
No pathways found





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