Gene description for Ralb
Gene name v-ral simian leukemia viral oncogene homolog B
Gene symbol Ralb
Other names/aliases dRalb
Species Rattus norvegicus
 Database cross references - Ralb
ExoCarta ExoCarta_116546
Entrez Gene 116546
UniProt P36860  
 Ralb identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Ralb
Molecular Function
    GTPase activity GO:0003924 ISS
    ubiquitin protein ligase binding GO:0031625 ISO
    ATPase binding GO:0051117 ISO
    GTP binding GO:0005525 NAS
    GDP binding GO:0019003 ISO
Biological Process
    Ras protein signal transduction GO:0007265 IEA
    apoptotic process GO:0006915 IEA
    regulation of exocyst localization GO:0060178 IDA
    positive regulation of autophagosome assembly GO:2000786 ISO
    cellular response to exogenous dsRNA GO:0071360 ISO
    negative regulation of protein binding GO:0032091 ISO
    cellular response to starvation GO:0009267 ISO
    positive regulation of protein serine/threonine kinase activity GO:0071902 ISO
    positive regulation of protein binding GO:0032092 ISO
    regulation of exocyst assembly GO:0001928 IDA
    positive regulation of protein phosphorylation GO:0001934 ISO
    metabolic process GO:0008152 ISS
Subcellular Localization
    midbody GO:0030496 ISS
    extracellular exosome GO:0070062 ISO
    plasma membrane GO:0005886 ISS
    cytosol GO:0005829 TAS
    exocyst GO:0000145 ISO
    autophagosome GO:0005776 ISO
 Experiment description of studies that identified Ralb in exosomes
1
Experiment ID 192
ISEV standards
CEM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
CD63|CD81|FLOT
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Ralb
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ralb is involved
PathwayEvidenceSource
p38MAPK events IEA Reactome





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