Gene description for Ggt1
Gene name gamma-glutamyltransferase 1
Gene symbol Ggt1
Other names/aliases GGLUT
Ggt
Ggtp
Species Rattus norvegicus
 Database cross references - Ggt1
ExoCarta ExoCarta_116568
Entrez Gene 116568
UniProt P07314  
 Ggt1 identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Ggt1
Molecular Function
    gamma-glutamyltransferase activity GO:0003840 NAS
    glutathione hydrolase activity GO:0036374 ISS
Biological Process
    glutathione biosynthetic process GO:0006750 ISO
    spermatogenesis GO:0007283 ISO
    glutathione catabolic process GO:0006751 ISS
    aging GO:0007568 IEP
    cysteine biosynthetic process GO:0019344 ISO
    zymogen activation GO:0031638 ISS
    regulation of immune system process GO:0002682 ISO
    leukotriene biosynthetic process GO:0019370 ISO
    cellular response to oxidative stress GO:0034599 IEP
    glutamate metabolic process GO:0006536 ISS
    response to estradiol GO:0032355 IEP
    response to lipopolysaccharide GO:0032496 IEP
    response to tumor necrosis factor GO:0034612 IEP
    regulation of inflammatory response GO:0050727 ISO
    peptide modification GO:0031179 IDA
Subcellular Localization
    membrane-bounded vesicle GO:0031988 ISO
    integral component of plasma membrane GO:0005887 TAS
    plasma membrane GO:0005886 ISS
    extracellular exosome GO:0070062 ISO
    extracellular space GO:0005615 ISO
 Experiment description of studies that identified Ggt1 in exosomes
1
Experiment ID 192
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
CD63|CD81|FLOT
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Ggt1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ggt1 is involved
No pathways found





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