Gene description for Ggt1
Gene name gamma-glutamyltransferase 1
Gene symbol Ggt1
Other names/aliases GGLUT
Ggt
Ggtp
Species Rattus norvegicus
 Database cross references - Ggt1
ExoCarta ExoCarta_116568
Vesiclepedia VP_116568
Entrez Gene 116568
UniProt P07314  
 Ggt1 identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Ggt1
Molecular Function
    peptidyltransferase activity GO:0000048 ISO
    leukotriene-C(4) hydrolase GO:0002951 ISO
    aminoacyltransferase activity GO:0016755 IDA
    glutathione hydrolase activity GO:0036374 IBA
    glutathione hydrolase activity GO:0036374 IEA
    glutathione hydrolase activity GO:0036374 ISO
    glutathione hydrolase activity GO:0036374 ISS
    leukotriene C4 gamma-glutamyl transferase activity GO:0103068 IEA
Biological Process
    regulation of immune system process GO:0002682 IBA
    regulation of immune system process GO:0002682 IEA
    regulation of immune system process GO:0002682 ISO
    proteolysis GO:0006508 ISO
    amino acid metabolic process GO:0006520 ISO
    glutamate metabolic process GO:0006536 ISO
    glutamate metabolic process GO:0006536 ISS
    fatty acid metabolic process GO:0006631 ISO
    leukotriene metabolic process GO:0006691 ISO
    glutathione biosynthetic process GO:0006750 IEA
    glutathione biosynthetic process GO:0006750 ISO
    glutathione catabolic process GO:0006751 IBA
    glutathione catabolic process GO:0006751 IEA
    glutathione catabolic process GO:0006751 ISO
    glutathione catabolic process GO:0006751 ISS
    spermatogenesis GO:0007283 IEA
    spermatogenesis GO:0007283 ISO
    cysteine biosynthetic process GO:0019344 IEA
    cysteine biosynthetic process GO:0019344 ISO
    peptide modification GO:0031179 IBA
    peptide modification GO:0031179 IDA
    zymogen activation GO:0031638 ISO
    zymogen activation GO:0031638 ISS
    response to estradiol GO:0032355 IEP
    response to lipopolysaccharide GO:0032496 IEP
    cellular response to oxidative stress GO:0034599 IEP
    response to tumor necrosis factor GO:0034612 IEP
    regulation of inflammatory response GO:0050727 IBA
    regulation of inflammatory response GO:0050727 IEA
    regulation of inflammatory response GO:0050727 ISO
    hepatoblast differentiation GO:0061017 IEP
    hepatocyte differentiation GO:0070365 IEP
    response to alcohol GO:0097305 IEP
    liver regeneration GO:0097421 IEP
    leukotriene D4 biosynthetic process GO:1901750 ISO
Subcellular Localization
    extracellular space GO:0005615 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    membrane GO:0016020 IEA
    vesicle GO:0031982 IEA
    vesicle GO:0031982 ISO
 Experiment description of studies that identified Ggt1 in exosomes
1
Experiment ID 192
MISEV standards
CEM
Biophysical techniques
TSG101|HSP70|CD63|CD81|FLOT
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M."
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Ggt1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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