Gene description for Ggt1
Gene name gamma-glutamyltransferase 1
Gene symbol Ggt1
Other names/aliases GGLUT
Ggt
Ggtp
Species Rattus norvegicus
 Database cross references - Ggt1
ExoCarta ExoCarta_116568
Vesiclepedia VP_116568
Entrez Gene 116568
UniProt P07314  
 Ggt1 identified in sEVs derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Ggt1
Molecular Function
    peptidyltransferase activity GO:0000048 ISO
    leukotriene-C(4) hydrolase GO:0002951 ISO
    aminoacyltransferase activity GO:0016755 IDA
    glutathione hydrolase activity GO:0036374 IBA
    glutathione hydrolase activity GO:0036374 IEA
    glutathione hydrolase activity GO:0036374 ISO
    glutathione hydrolase activity GO:0036374 ISS
    leukotriene C4 gamma-glutamyl transferase activity GO:0103068 IEA
Biological Process
    regulation of immune system process GO:0002682 IBA
    regulation of immune system process GO:0002682 IEA
    regulation of immune system process GO:0002682 ISO
    proteolysis GO:0006508 ISO
    amino acid metabolic process GO:0006520 ISO
    glutamate metabolic process GO:0006536 ISO
    glutamate metabolic process GO:0006536 ISS
    fatty acid metabolic process GO:0006631 ISO
    leukotriene metabolic process GO:0006691 ISO
    glutathione biosynthetic process GO:0006750 IEA
    glutathione biosynthetic process GO:0006750 ISO
    glutathione catabolic process GO:0006751 IBA
    glutathione catabolic process GO:0006751 IEA
    glutathione catabolic process GO:0006751 ISO
    glutathione catabolic process GO:0006751 ISS
    spermatogenesis GO:0007283 IEA
    spermatogenesis GO:0007283 ISO
    cysteine biosynthetic process GO:0019344 IEA
    cysteine biosynthetic process GO:0019344 ISO
    peptide modification GO:0031179 IBA
    peptide modification GO:0031179 IDA
    zymogen activation GO:0031638 ISO
    zymogen activation GO:0031638 ISS
    response to estradiol GO:0032355 IEP
    response to lipopolysaccharide GO:0032496 IEP
    cellular response to oxidative stress GO:0034599 IEP
    response to tumor necrosis factor GO:0034612 IEP
    regulation of inflammatory response GO:0050727 IBA
    regulation of inflammatory response GO:0050727 IEA
    regulation of inflammatory response GO:0050727 ISO
    hepatoblast differentiation GO:0061017 IEP
    hepatocyte differentiation GO:0070365 IEP
    response to alcohol GO:0097305 IEP
    liver regeneration GO:0097421 IEP
    leukotriene D4 biosynthetic process GO:1901750 ISO
Subcellular Localization
    extracellular space GO:0005615 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    membrane GO:0016020 IEA
    vesicle GO:0031982 IEA
    vesicle GO:0031982 ISO
 Experiment description of studies that identified Ggt1 in sEVs
1
Experiment ID 192
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M."
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Ggt1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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