Gene description for Oplah
Gene name 5-oxoprolinase (ATP-hydrolysing)
Gene symbol Oplah
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Oplah
ExoCarta ExoCarta_116684
Entrez Gene 116684
UniProt P97608  
 Oplah identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Oplah
Molecular Function
    5-oxoprolinase (ATP-hydrolyzing) activity GO:0017168 IEA
    ATP binding GO:0005524 IEA
Biological Process
    metabolic process GO:0008152 IEA
 Experiment description of studies that identified Oplah in exosomes
Experiment ID 95
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Oplah
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Oplah is involved
Glutathione synthesis and recycling IEA Reactome

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