Gene description for Abcc5
Gene name ATP-binding cassette, subfamily C (CFTR/MRP), member 5
Gene symbol Abcc5
Other names/aliases Abcc5a
Mrp5
Species Rattus norvegicus
 Database cross references - Abcc5
ExoCarta ExoCarta_116721
Entrez Gene 116721
UniProt Q9QYM0  
 Abcc5 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Abcc5
Molecular Function
    ATP binding GO:0005524 IEA
    molecular_function GO:0003674 ND
    organic anion transmembrane transporter activity GO:0008514 IEA
    ATPase activity, coupled to transmembrane movement of substances GO:0042626 IEA
Biological Process
    metabolic process GO:0008152 IEA
    response to lipopolysaccharide GO:0032496 IEP
    transmembrane transport GO:0055085 IEA
    organic anion transport GO:0015711 IEA
    response to insulin GO:0032868 IEP
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 IDA
    integral component of membrane GO:0016021 IEA
    membrane GO:0016020 ISO
 Experiment description of studies that identified Abcc5 in exosomes
1
Experiment ID 90
ISEV standards
EM
EV Biophysical techniques
HSC70|HSP90|TSG101
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 94
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Abcc5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Abcc5 is involved
No pathways found





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