Gene description for Rims2
Gene name regulating synaptic membrane exocytosis 2
Gene symbol Rims2
Other names/aliases 2810036I15Rik
AW048769
RIM2
Rab3ip2
Rim2(+40A)
Rim2(+44A)
Rim2(+4A)
Serg2
Syt3-rs
mKIAA0751
Species Mus musculus
 Database cross references - Rims2
ExoCarta ExoCarta_116838
Entrez Gene 116838
UniProt Q9EQZ7  
 Rims2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Rims2
Molecular Function
    metal ion binding GO:0046872 IEA
    Rab GTPase binding GO:0017137 IEA
    protein domain specific binding GO:0019904 ISO
    protein binding GO:0005515 IPI
    ion channel binding GO:0044325 IDA
    protein heterodimerization activity GO:0046982 ISO
Biological Process
    regulation of exocytosis GO:0017157 IMP
    intracellular protein transport GO:0006886 IEA
    cAMP-mediated signaling GO:0019933 IDA
    exocytosis GO:0006887 IEA
    insulin secretion GO:0030073 IMP
    positive regulation of inhibitory postsynaptic membrane potential GO:0097151 IGI
    spontaneous neurotransmitter secretion GO:0061669 IGI
    calcium ion-dependent exocytosis of neurotransmitter GO:0048791 IGI
    regulation of synaptic vesicle exocytosis GO:2000300 ISO
    transport GO:0006810 IEA
    positive regulation of dendrite extension GO:1903861 ISO
    neurotransmitter transport GO:0006836 IEA
    positive regulation of gene expression GO:0010628 IGI
    regulation of membrane potential GO:0042391 IDA
    positive regulation of excitatory postsynaptic membrane potential GO:2000463 IGI
    calcium ion-dependent exocytosis GO:0017156 IDA
Subcellular Localization
    protein complex GO:0043234 ISO
    extracellular exosome GO:0070062 ISO
    cell junction GO:0030054 IEA
    neuron projection GO:0043005 IEA
    cell GO:0005623 IGI
    synapse GO:0045202 ISO
    intracellular GO:0005622 IDA
 Experiment description of studies that identified Rims2 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Rims2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Rims2 is involved
No pathways found





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