Gene description for Amd1
Gene name S-adenosylmethionine decarboxylase 1
Gene symbol Amd1
Other names/aliases 1
AdoMetDC
Amd-1
SAMDC
SAMDC 1
adoMetDC1
Species Mus musculus
 Database cross references - Amd1
ExoCarta ExoCarta_11702
Vesiclepedia VP_11702
Entrez Gene 11702
UniProt P0DMN7  
 Amd1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Amd1
Molecular Function
    adenosylmethionine decarboxylase activity GO:0004014 IBA
    adenosylmethionine decarboxylase activity GO:0004014 IEA
    adenosylmethionine decarboxylase activity GO:0004014 ISO
    protein binding GO:0005515 IPI
    putrescine binding GO:0019810 IBA
    putrescine binding GO:0019810 ISO
    identical protein binding GO:0042802 ISO
Biological Process
    polyamine metabolic process GO:0006595 ISO
    spermine biosynthetic process GO:0006597 IBA
    spermine biosynthetic process GO:0006597 IEA
    spermine biosynthetic process GO:0006597 ISO
    spermidine biosynthetic process GO:0008295 IBA
    spermidine biosynthetic process GO:0008295 IEA
    spermidine biosynthetic process GO:0008295 ISO
    S-adenosylmethionine metabolic process GO:0046500 ISO
Subcellular Localization
    cytosol GO:0005829 IBA
 Experiment description of studies that identified Amd1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Amd1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Atg12  
Positive Genetic Mus musculus
View the network image/svg+xml
 Pathways in which Amd1 is involved
PathwayEvidenceSource
Metabolism IEA Reactome
Metabolism of amino acids and derivatives IEA Reactome
Metabolism of polyamines IEA Reactome





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