Gene description for Amd1
Gene name S-adenosylmethionine decarboxylase 1
Gene symbol Amd1
Other names/aliases 1
AdoMetDC
Amd-1
SAMDC
SAMDC 1
adoMetDC1
Species Mus musculus
 Database cross references - Amd1
ExoCarta ExoCarta_11702
Entrez Gene 11702
UniProt P0DMN7  
 Amd1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Amd1
Molecular Function
    protein binding GO:0005515 IPI
    putrescine binding GO:0019810 ISO
    adenosylmethionine decarboxylase activity GO:0004014 ISO
    carboxy-lyase activity GO:0016831 IEA
    lyase activity GO:0016829 IEA
Biological Process
    spermine biosynthetic process GO:0006597 IDA
    in utero embryonic development GO:0001701 IMP
    polyamine biosynthetic process GO:0006596 IEA
    spermidine biosynthetic process GO:0008295 IDA
Subcellular Localization
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Amd1 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Amd1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Amd1 is involved
PathwayEvidenceSource
Metabolism of polyamines IEA Reactome





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