Gene description for Ppp2r2a
Gene name protein phosphatase 2, regulatory subunit B, alpha
Gene symbol Ppp2r2a
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Ppp2r2a
ExoCarta ExoCarta_117104
Vesiclepedia VP_117104
Entrez Gene 117104
UniProt P36876  
 Ppp2r2a identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Ppp2r2a
Molecular Function
    protein binding GO:0005515 IPI
    protein phosphatase regulator activity GO:0019888 IBA
    protein phosphatase regulator activity GO:0019888 IEA
    protein phosphatase regulator activity GO:0019888 ISO
    protein phosphatase regulator activity GO:0019888 ISS
    protein-containing complex binding GO:0044877 IPI
    tau protein binding GO:0048156 IPI
    protein phosphatase 2A binding GO:0051721 IPI
    enzyme-substrate adaptor activity GO:0140767 ISS
Biological Process
    protein dephosphorylation GO:0006470 ISO
    protein dephosphorylation GO:0006470 ISS
    response to morphine GO:0043278 IEA
    response to morphine GO:0043278 ISO
    regulation of chromosome segregation GO:0051983 ISS
Subcellular Localization
    protein phosphatase type 2A complex GO:0000159 IBA
    protein phosphatase type 2A complex GO:0000159 IEA
    protein phosphatase type 2A complex GO:0000159 ISO
    protein phosphatase type 2A complex GO:0000159 ISS
    cytosol GO:0005829 IBA
    synapse GO:0045202 ISO
    glutamatergic synapse GO:0098978 IEA
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Ppp2r2a in sEVs
1
Experiment ID 92
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|GAPDH|CD9|CD151
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|GAPDH|CD9|CD151
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Ppp2r2a
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Slc8a1  
Affinity Capture-MS Rattus norvegicus
2 Slc8a1  
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
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