Gene description for Ppp2r2a
Gene name protein phosphatase 2, regulatory subunit B, alpha
Gene symbol Ppp2r2a
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Ppp2r2a
ExoCarta ExoCarta_117104
Entrez Gene 117104
UniProt P36876  
 Ppp2r2a identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Ppp2r2a
Molecular Function
    protein complex binding GO:0032403 IPI
    protein phosphatase type 2A regulator activity GO:0008601 IEA
    protein binding GO:0005515 IPI
    tau protein binding GO:0048156 IPI
    protein phosphatase 2A binding GO:0051721 IPI
    protein serine/threonine phosphatase activity GO:0004722 ISO
Biological Process
    protein dephosphorylation GO:0006470 ISO
    regulation of protein phosphatase type 2A activity GO:0034047 IEA
    signal transduction GO:0007165 IEA
    response to morphine GO:0043278 ISO
Subcellular Localization
    protein phosphatase type 2A complex GO:0000159 ISO
 Experiment description of studies that identified Ppp2r2a in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Ppp2r2a
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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