Gene description for Acsl6
Gene name acyl-CoA synthetase long-chain family member 6
Gene symbol Acsl6
Other names/aliases Facl6
Lacsl
Species Rattus norvegicus
 Database cross references - Acsl6
ExoCarta ExoCarta_117243
Vesiclepedia VP_117243
Entrez Gene 117243
UniProt P33124  
 Acsl6 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
Hepatocytes 19367702    
 Gene ontology annotations for Acsl6
Molecular Function
    long-chain fatty acid-CoA ligase activity GO:0004467 IDA
    long-chain fatty acid-CoA ligase activity GO:0004467 IEA
    long-chain fatty acid-CoA ligase activity GO:0004467 ISO
    ATP binding GO:0005524 IEA
    enzyme binding GO:0019899 ISO
    protein homodimerization activity GO:0042803 IDA
    protein homodimerization activity GO:0042803 IEA
    protein homodimerization activity GO:0042803 ISO
    arachidonate-CoA ligase activity GO:0047676 IBA
    arachidonate-CoA ligase activity GO:0047676 IDA
Biological Process
    very long-chain fatty acid metabolic process GO:0000038 IBA
    response to hypoxia GO:0001666 IEP
    long-chain fatty acid metabolic process GO:0001676 IBA
    long-chain fatty acid metabolic process GO:0001676 IDA
    long-chain fatty acid metabolic process GO:0001676 IEA
    long-chain fatty acid metabolic process GO:0001676 ISO
    neuroblast proliferation GO:0007405 IEA
    neuroblast proliferation GO:0007405 ISO
    response to nutrient GO:0007584 IEP
    lipid biosynthetic process GO:0008610 IEA
    phospholipid biosynthetic process GO:0008654 IMP
    response to gravity GO:0009629 IEP
    positive regulation of long-chain fatty acid import across plasma membrane GO:0010747 IMP
    positive regulation of neuron projection development GO:0010976 IMP
    fatty acid transport GO:0015908 IGI
    triglyceride biosynthetic process GO:0019432 IGI
    cellular response to insulin stimulus GO:0032869 IEP
    long-chain fatty-acyl-CoA biosynthetic process GO:0035338 IBA
    long-chain fatty-acyl-CoA biosynthetic process GO:0035338 IGI
    response to steroid hormone GO:0048545 IEP
    neuron development GO:0048666 IEP
Subcellular Localization
    mitochondrial outer membrane GO:0005741 IEA
    peroxisomal membrane GO:0005778 IEA
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum GO:0005783 ISS
    endoplasmic reticulum membrane GO:0005789 IEA
    membrane GO:0016020 IBA
    membrane GO:0016020 ISO
 Experiment description of studies that identified Acsl6 in sEVs
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 35
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|CD81|CD63
Enriched markers
HSPA5
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Acsl6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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