Gene description for Ptpn12
Gene name protein tyrosine phosphatase, non-receptor type 12
Gene symbol Ptpn12
Other names/aliases Ptpg1
RKPTP
Species Rattus norvegicus
 Database cross references - Ptpn12
ExoCarta ExoCarta_117255
Entrez Gene 117255
 Ptpn12 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Ptpn12
Molecular Function
    SH3 domain binding GO:0017124 ISO
    phosphoprotein phosphatase activity GO:0004721 ISO
    protein tyrosine phosphatase activity GO:0004725 IDA
Biological Process
    protein dephosphorylation GO:0006470 ISO
    tissue regeneration GO:0042246 IEP
    peptidyl-tyrosine dephosphorylation GO:0035335 IEA
Subcellular Localization
    cellular_component GO:0005575 ND
    cytoplasm GO:0005737 ISO
    podosome GO:0002102 ISO
    plasma membrane GO:0005886 ISO
    cytosol GO:0005829 NAS
 Experiment description of studies that identified Ptpn12 in exosomes
1
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Ptpn12
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ptpn12 is involved
No pathways found





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