Gene description for Rhoa
Gene name	ras homolog family member A
Gene symbol	Rhoa
Other names/aliases	Arha Arha2
Species	Rattus norvegicus
Database cross references - Rhoa
ExoCarta	ExoCarta_117273
Vesiclepedia	VP_117273
Entrez Gene	117273
UniProt	P61589
Rhoa identified in exosomes derived from the following tissue/cell type
Hepatocytes	19367702
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Urine	20535238

Gene ontology annotations for Rhoa

Molecular Function     GTPase activity GO:0003924 IBA     GTPase activity GO:0003924 IDA     GTPase activity GO:0003924 IEA     GTPase activity GO:0003924 ISO     GTPase activity GO:0003924 NAS     GTPase activity GO:0003924 TAS     G protein activity GO:0003925 IEA     protein binding GO:0005515 IPI     GTP binding GO:0005525 IBA     GTP binding GO:0005525 IDA     GTP binding GO:0005525 IEA     GTP binding GO:0005525 ISO     GTP binding GO:0005525 TAS     myosin binding GO:0017022 IEA     myosin binding GO:0017022 ISO     GDP binding GO:0019003 IDA     protein kinase binding GO:0019901 IBA     protein domain specific binding GO:0019904 IPI     Rho GDP-dissociation inhibitor binding GO:0051022 IPI     membrane scission GTPase motor activity GO:1990606 IEA Biological Process     meiotic spindle organization GO:0000212 ISO     cell morphogenesis GO:0000902 ISO     response to hypoxia GO:0001666 IEP     neuron migration GO:0001764 ISO     kidney development GO:0001822 ISO     angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure GO:0001998 ISO     alpha-beta T cell lineage commitment GO:0002363 ISO     regulation of systemic arterial blood pressure by endothelin GO:0003100 ISO     aortic valve formation GO:0003189 IEA     aortic valve formation GO:0003189 ISO     regulation of transcription by RNA polymerase II GO:0006357 ISO     cytoskeleton organization GO:0007010 ISO     microtubule depolymerization GO:0007019 IMP     cell adhesion GO:0007155 ISO     cell-matrix adhesion GO:0007160 ISO     small GTPase-mediated signal transduction GO:0007264 IEA     Rho protein signal transduction GO:0007266 IBA     Rho protein signal transduction GO:0007266 IEA     Rho protein signal transduction GO:0007266 IMP     Rho protein signal transduction GO:0007266 ISO     Rho protein signal transduction GO:0007266 ISS     skeletal muscle tissue development GO:0007519 ISO     regulation of actin polymerization or depolymerization GO:0008064 IEP     response to xenobiotic stimulus GO:0009410 IDA     response to xenobiotic stimulus GO:0009410 IEP     response to mechanical stimulus GO:0009612 IEP     response to glucose GO:0009749 IEP     negative regulation of cell-substrate adhesion GO:0010812 ISO     regulation of neuron projection development GO:0010975 ISO     negative regulation of neuron projection development GO:0010977 IGI     cell migration GO:0016477 IBA     cell migration GO:0016477 ISO     cell migration GO:0016477 ISS     substantia nigra development GO:0021762 ISO     cerebral cortex cell migration GO:0021795 ISO     forebrain radial glial cell differentiation GO:0021861 ISO     actin cytoskeleton organization GO:0030036 ISO     actin cytoskeleton organization GO:0030036 ISO     actin cytoskeleton organization GO:0030036 ISS     actin cytoskeleton organization GO:0030036 TAS     cell differentiation GO:0030154 ISO     positive regulation of cell growth GO:0030307 IEP     positive regulation of cell growth GO:0030307 IMP     regulation of cell migration GO:0030334 ISO     regulation of cell migration GO:0030334 ISS     positive regulation of cell migration GO:0030335 IEP     androgen receptor signaling pathway GO:0030521 ISO     positive regulation of actin filament polymerization GO:0030838 IMP     establishment or maintenance of actin cytoskeleton polarity GO:0030950 ISO     stress-activated protein kinase signaling cascade GO:0031098 IMP     cytoplasmic microtubule organization GO:0031122 IEA     cytoplasmic microtubule organization GO:0031122 ISO     positive regulation of cytokinesis GO:0032467 IEA     positive regulation of cytokinesis GO:0032467 ISO     positive regulation of cytokinesis GO:0032467 ISS     regulation of actin cytoskeleton organization GO:0032956 IBA     regulation of actin cytoskeleton organization GO:0032956 ISO     negative regulation of intracellular steroid hormone receptor signaling pathway GO:0033144 ISO     regulation of osteoblast proliferation GO:0033688 ISO     cell junction assembly GO:0034329 ISO     cell junction assembly GO:0034329 ISS     substrate adhesion-dependent cell spreading GO:0034446 IEA     substrate adhesion-dependent cell spreading GO:0034446 ISO     Roundabout signaling pathway GO:0035385 IEA     Roundabout signaling pathway GO:0035385 ISO     Roundabout signaling pathway GO:0035385 ISS     cleavage furrow formation GO:0036089 ISO     cleavage furrow formation GO:0036089 ISS     apolipoprotein A-I-mediated signaling pathway GO:0038027 IEA     apolipoprotein A-I-mediated signaling pathway GO:0038027 ISO     embryonic cleavage GO:0040016 ISO     polar body extrusion after meiotic divisions GO:0040038 ISO     odontogenesis GO:0042476 ISO     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEA     positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISO     positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISS     negative regulation of canonical NF-kappaB signal transduction GO:0043124 IMP     stress fiber assembly GO:0043149 IBA     stress fiber assembly GO:0043149 IEA     stress fiber assembly GO:0043149 ISO     stress fiber assembly GO:0043149 ISO     stress fiber assembly GO:0043149 ISS     response to amino acid GO:0043200 IEP     apical junction assembly GO:0043297 IEA     apical junction assembly GO:0043297 ISO     apical junction assembly GO:0043297 ISS     beta selection GO:0043366 ISO     positive regulation of neuron apoptotic process GO:0043525 IMP     endothelial cell migration GO:0043542 IEA     endothelial cell migration GO:0043542 ISO     ossification involved in bone maturation GO:0043931 ISO     wound healing, spreading of cells GO:0044319 ISS     establishment of epithelial cell apical/basal polarity GO:0045198 IEA     establishment of epithelial cell apical/basal polarity GO:0045198 ISO     establishment of epithelial cell apical/basal polarity GO:0045198 ISS     response to ethanol GO:0045471 IEP     negative regulation of neuron differentiation GO:0045665 IMP     positive regulation of neuron differentiation GO:0045666 IEA     positive regulation of neuron differentiation GO:0045666 ISO     positive regulation of translation GO:0045727 IEP     positive regulation of cell adhesion GO:0045785 IEP     negative regulation of cell size GO:0045792 IEA     negative regulation of cell size GO:0045792 ISO     positive regulation of vasoconstriction GO:0045907 IEP     positive regulation of smooth muscle contraction GO:0045987 IMP     GTP metabolic process GO:0046039 IDA     positive regulation of alpha-beta T cell differentiation GO:0046638 ISO     neuron projection morphogenesis GO:0048812 IEP     regulation of dendrite development GO:0050773 IMP     negative chemotaxis GO:0050919 IEA     negative chemotaxis GO:0050919 ISO     response to glucocorticoid GO:0051384 IEP     positive regulation of stress fiber assembly GO:0051496 IEA     positive regulation of stress fiber assembly GO:0051496 ISO     positive regulation of stress fiber assembly GO:0051496 ISO     spindle localization GO:0051653 ISO     regulation of calcium ion transport GO:0051924 IMP     negative regulation of synapse assembly GO:0051964 IMP     positive regulation of lipase activity GO:0060193 ISO     bone trabecula morphogenesis GO:0061430 ISO     regulation of microtubule cytoskeleton organization GO:0070507 ISO     cellular response to lipopolysaccharide GO:0071222 IEA     cellular response to lipopolysaccharide GO:0071222 ISO     cellular response to cytokine stimulus GO:0071345 ISO     cellular response to progesterone stimulus GO:0071393 NAS     semaphorin-plexin signaling pathway GO:0071526 ISO     positive regulation of podosome assembly GO:0071803 ISO     positive regulation of protein serine/threonine kinase activity GO:0071902 ISO     positive regulation of protein serine/threonine kinase activity GO:0071902 ISS     negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 IEA     negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 ISO     mitotic spindle assembly GO:0090307 IEA     mitotic spindle assembly GO:0090307 ISO     negative regulation of oxidative phosphorylation GO:0090324 ISO     motor neuron apoptotic process GO:0097049 ISO     endothelial tube lumen extension GO:0097498 IEA     endothelial tube lumen extension GO:0097498 ISO     regulation of modification of postsynaptic structure GO:0099159 ISO     skeletal muscle satellite cell migration GO:1902766 ISS     negative regulation of reactive oxygen species biosynthetic process GO:1903427 ISO     mitotic cleavage furrow formation GO:1903673 IEA     mitotic cleavage furrow formation GO:1903673 ISO     mitotic cleavage furrow formation GO:1903673 ISS     positive regulation of vascular associated smooth muscle contraction GO:1904695 ISO     negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 IMP     negative regulation of vascular associated smooth muscle cell migration GO:1904753 IMP     positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 IEA     positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 ISO     regulation of modification of postsynaptic actin cytoskeleton GO:1905274 IEA     regulation of modification of postsynaptic actin cytoskeleton GO:1905274 ISO     cellular response to chemokine GO:1990869 IEA     cellular response to chemokine GO:1990869 ISO     cellular response to chemokine GO:1990869 ISS     regulation of neural precursor cell proliferation GO:2000177 ISO     positive regulation of T cell migration GO:2000406 IEA     positive regulation of T cell migration GO:2000406 ISO     positive regulation of T cell migration GO:2000406 ISS     negative regulation of motor neuron apoptotic process GO:2000672 ISO Subcellular Localization     nucleus GO:0005634 ISO     endosome GO:0005768 IEA     endosome GO:0005768 ISO     cytosol GO:0005829 IBA     cytosol GO:0005829 IDA     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     cytoskeleton GO:0005856 IEA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 ISO     cell cortex GO:0005938 IEA     cell cortex GO:0005938 ISO     cell cortex GO:0005938 ISS     cytoplasmic side of plasma membrane GO:0009898 IEA     cytoplasmic side of plasma membrane GO:0009898 ISO     cytoplasmic side of plasma membrane GO:0009898 ISS     membrane GO:0016020 IDA     lamellipodium GO:0030027 ISO     lamellipodium GO:0030027 ISS     axon GO:0030424 IDA     dendrite GO:0030425 IDA     midbody GO:0030496 IEA     vesicle GO:0031982 ISO     cleavage furrow GO:0032154 IBA     cleavage furrow GO:0032154 IEA     cleavage furrow GO:0032154 ISO     cleavage furrow GO:0032154 ISS     ruffle membrane GO:0032587 ISO     neuronal cell body GO:0043025 IDA     dendritic spine GO:0043197 IBA     dendritic spine GO:0043197 IDA     apical junction complex GO:0043296 IEA     apical junction complex GO:0043296 ISO     apical junction complex GO:0043296 ISS     cell periphery GO:0071944 ISO     meiotic spindle GO:0072687 ISO     postsynapse GO:0098794 IEA     postsynapse GO:0098794 ISO     glutamatergic synapse GO:0098978 IEA     glutamatergic synapse GO:0098978 ISO