Gene description for Hnrnpu
Gene name	heterogeneous nuclear ribonucleoprotein U
Gene symbol	Hnrnpu
Other names/aliases	Hnrpu SN1
Species	Rattus norvegicus
Database cross references - Hnrnpu
ExoCarta	ExoCarta_117280
Vesiclepedia	VP_117280
Entrez Gene	117280
Hnrnpu identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells	20124479
Pancreatic cancer cells	20124479

Gene ontology annotations for Hnrnpu

Molecular Function     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 ISO     RNA polymerase II complex binding GO:0000993 IEA     RNA polymerase II complex binding GO:0000993 ISO     TFIIH-class transcription factor complex binding GO:0001097 IEA     TFIIH-class transcription factor complex binding GO:0001097 ISO     DNA binding GO:0003677 ISO     chromatin binding GO:0003682 ISO     chromatin binding GO:0003682 ISS     double-stranded DNA binding GO:0003690 ISO     single-stranded DNA binding GO:0003697 IEA     single-stranded DNA binding GO:0003697 ISO     transcription corepressor activity GO:0003714 IEA     transcription corepressor activity GO:0003714 ISO     RNA binding GO:0003723 IBA     RNA binding GO:0003723 IDA     RNA binding GO:0003723 ISO     double-stranded RNA binding GO:0003725 IEA     double-stranded RNA binding GO:0003725 ISO     single-stranded RNA binding GO:0003727 ISO     mRNA 3'-UTR binding GO:0003730 IEA     mRNA 3'-UTR binding GO:0003730 ISO     actin binding GO:0003779 IEA     actin binding GO:0003779 ISO     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     ATP binding GO:0005524 ISO     ATP binding GO:0005524 ISS     poly(A) binding GO:0008143 IEA     poly(A) binding GO:0008143 ISO     snRNA binding GO:0017069 IEA     snRNA binding GO:0017069 ISO     poly(C) RNA binding GO:0017130 IEA     poly(C) RNA binding GO:0017130 ISO     chromatin DNA binding GO:0031490 IEA     chromatin DNA binding GO:0031490 ISO     poly(G) binding GO:0034046 IDA     poly(G) binding GO:0034046 IEA     poly(G) binding GO:0034046 ISO     piRNA binding GO:0034584 IEA     piRNA binding GO:0034584 ISO     pre-mRNA binding GO:0036002 IEA     pre-mRNA binding GO:0036002 ISO     identical protein binding GO:0042802 IEA     identical protein binding GO:0042802 ISO     identical protein binding GO:0042802 ISS     ribonucleoprotein complex binding GO:0043021 IEA     ribonucleoprotein complex binding GO:0043021 IPI     ribonucleoprotein complex binding GO:0043021 ISO     sequence-specific DNA binding GO:0043565 ISO     sequence-specific DNA binding GO:0043565 ISS     protein-containing complex binding GO:0044877 ISO     telomerase RNA binding GO:0070034 IEA     telomerase RNA binding GO:0070034 ISO     RNA polymerase II C-terminal domain binding GO:0099122 ISO     RNA polymerase II C-terminal domain binding GO:0099122 ISS     lncRNA binding GO:0106222 ISO     sequence-specific double-stranded DNA binding GO:1990837 IEA     sequence-specific double-stranded DNA binding GO:1990837 ISO     promoter-specific chromatin binding GO:1990841 IBA     promoter-specific chromatin binding GO:1990841 IDA     promoter-specific chromatin binding GO:1990841 ISO     promoter-specific chromatin binding GO:1990841 ISS Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IEA     negative regulation of transcription by RNA polymerase II GO:0000122 ISO     alternative mRNA splicing, via spliceosome GO:0000380 IBA     regulation of alternative mRNA splicing, via spliceosome GO:0000381 IEA     regulation of alternative mRNA splicing, via spliceosome GO:0000381 ISO     mRNA processing GO:0006397 IEA     regulation of mitotic cell cycle GO:0007346 IEA     regulation of mitotic cell cycle GO:0007346 ISO     regulation of mitotic cell cycle GO:0007346 ISS     RNA splicing GO:0008380 IEA     dosage compensation by inactivation of X chromosome GO:0009048 ISO     positive regulation of gene expression GO:0010628 IMP     mRNA metabolic process GO:0016071 ISO     erythrocyte differentiation GO:0030218 ISO     regulatory ncRNA-mediated heterochromatin formation GO:0031048 IEA     regulatory ncRNA-mediated heterochromatin formation GO:0031048 ISO     negative regulation of telomere maintenance via telomerase GO:0032211 IEA     negative regulation of telomere maintenance via telomerase GO:0032211 ISO     circadian regulation of gene expression GO:0032922 ISO     negative regulation of kinase activity GO:0033673 ISO     negative regulation of transcription elongation by RNA polymerase II GO:0034244 IEA     negative regulation of transcription elongation by RNA polymerase II GO:0034244 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 IBA     positive regulation of transcription by RNA polymerase II GO:0045944 IEA     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 ISS     mRNA stabilization GO:0048255 ISO     cell division GO:0051301 IEA     maintenance of protein location in nucleus GO:0051457 IEA     maintenance of protein location in nucleus GO:0051457 ISO     cardiac muscle cell development GO:0055013 ISO     random inactivation of X chromosome GO:0060816 IEA     random inactivation of X chromosome GO:0060816 ISO     CRD-mediated mRNA stabilization GO:0070934 IEA     CRD-mediated mRNA stabilization GO:0070934 ISO     cellular response to glucocorticoid stimulus GO:0071385 IEA     cellular response to glucocorticoid stimulus GO:0071385 ISO     cellular response to dexamethasone stimulus GO:0071549 IDA     positive regulation of brown fat cell differentiation GO:0090336 ISO     positive regulation of brown fat cell differentiation GO:0090336 ISS     dendritic transport of messenger ribonucleoprotein complex GO:0098963 ISO     negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:1900152 IEA     negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:1900152 ISO     regulation of mitotic spindle assembly GO:1901673 IEA     regulation of mitotic spindle assembly GO:1901673 ISO     regulation of mitotic spindle assembly GO:1901673 ISS     regulation of chromatin organization GO:1902275 IEA     regulation of chromatin organization GO:1902275 ISO     regulation of chromatin organization GO:1902275 ISS     positive regulation of attachment of mitotic spindle microtubules to kinetochore GO:1902425 IEA     positive regulation of attachment of mitotic spindle microtubules to kinetochore GO:1902425 ISO     positive regulation of attachment of mitotic spindle microtubules to kinetochore GO:1902425 ISS     protein localization to spindle microtubule GO:1902889 IEA     protein localization to spindle microtubule GO:1902889 ISO     protein localization to spindle microtubule GO:1902889 ISS     RNA localization to chromatin GO:1990280 ISO     cellular response to leukemia inhibitory factor GO:1990830 ISO     cellular response to leukemia inhibitory factor GO:1990830 ISS     adaptive thermogenesis GO:1990845 ISO     adaptive thermogenesis GO:1990845 ISS     positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity GO:2000373 IDA     positive regulation of stem cell proliferation GO:2000648 ISO     negative regulation of stem cell differentiation GO:2000737 IEA     negative regulation of stem cell differentiation GO:2000737 ISO     negative regulation of stem cell differentiation GO:2000737 ISS     positive regulation of cytoplasmic translation GO:2000767 IEA     positive regulation of cytoplasmic translation GO:2000767 ISO Subcellular Localization     nuclear chromosome GO:0000228 IEA     nuclear chromosome GO:0000228 ISO     kinetochore GO:0000776 IEA     kinetochore GO:0000776 ISO     kinetochore GO:0000776 ISS     spindle pole GO:0000922 IEA     nucleus GO:0005634 IBA     nucleus GO:0005634 IEA     nucleus GO:0005634 ISO     nucleoplasm GO:0005654 ISO     telomerase holoenzyme complex GO:0005697 IEA     telomerase holoenzyme complex GO:0005697 ISO     centrosome GO:0005813 IEA     centrosome GO:0005813 ISO     centrosome GO:0005813 ISS     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     cell surface GO:0009986 IEA     cell surface GO:0009986 ISO     nuclear matrix GO:0016363 IEA     nuclear matrix GO:0016363 ISO     nuclear speck GO:0016607 IEA     nuclear speck GO:0016607 ISO     midbody GO:0030496 IEA     midbody GO:0030496 ISO     midbody GO:0030496 ISS     protein-containing complex GO:0032991 ISO     cytoplasmic ribonucleoprotein granule GO:0036464 IEA     cytoplasmic ribonucleoprotein granule GO:0036464 ISO     CRD-mediated mRNA stability complex GO:0070937 IEA     CRD-mediated mRNA stability complex GO:0070937 ISO     catalytic step 2 spliceosome GO:0071013 IEA     catalytic step 2 spliceosome GO:0071013 ISO     mitotic spindle GO:0072686 ISO     mitotic spindle GO:0072686 ISS     RNA polymerase II transcription regulator complex GO:0090575 IEA     RNA polymerase II transcription regulator complex GO:0090575 ISO     inactive sex chromosome GO:0098577 IEA     inactive sex chromosome GO:0098577 ISO     mitotic spindle midzone GO:1990023 IEA     mitotic spindle midzone GO:1990023 ISO     mitotic spindle midzone GO:1990023 ISS     mitotic spindle microtubule GO:1990498 IEA     mitotic spindle microtubule GO:1990498 ISO     mitotic spindle microtubule GO:1990498 ISS     ribonucleoprotein complex GO:1990904 IBA     ribonucleoprotein complex GO:1990904 IDA     ribonucleoprotein complex GO:1990904 ISO