Gene description for Anxa8
Gene name annexin A8
Gene symbol Anxa8
Other names/aliases AI466995
Anx8
Species Mus musculus
 Database cross references - Anxa8
ExoCarta ExoCarta_11752
Vesiclepedia VP_11752
Entrez Gene 11752
UniProt O35640  
 Anxa8 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Anxa8
Molecular Function
    phosphatidylserine binding GO:0001786 IBA
    calcium ion binding GO:0005509 IEA
    calcium ion binding GO:0005509 ISO
    calcium-dependent phospholipid binding GO:0005544 IBA
    calcium-dependent phospholipid binding GO:0005544 IEA
    calcium-dependent phospholipid binding GO:0005544 ISO
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 ISO
    phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 ISO
    phosphatidylinositol-3,4-bisphosphate binding GO:0043325 ISO
    actin filament binding GO:0051015 ISO
Biological Process
    endosome organization GO:0007032 IBA
    endosome organization GO:0007032 ISO
    blood coagulation GO:0007596 IEA
    endosomal transport GO:0016197 IBA
    endosomal transport GO:0016197 ISO
    negative regulation of serine-type endopeptidase activity GO:1900004 ISO
    negative regulation of phospholipase A2 activity GO:1900138 ISO
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 ISO
    vesicle membrane GO:0012506 IBA
    late endosome membrane GO:0031902 ISO
    sarcolemma GO:0042383 IBA
 Experiment description of studies that identified Anxa8 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Anxa8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Anxa8 is involved
No pathways found





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