Gene description for Uba3
Gene name ubiquitin-like modifier activating enzyme 3
Gene symbol Uba3
Other names/aliases Ube1c
Species Rattus norvegicus
 Database cross references - Uba3
ExoCarta ExoCarta_117553
Entrez Gene 117553
UniProt Q99MI7  
 Uba3 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Uba3
Molecular Function
    acid-amino acid ligase activity GO:0016881 IEA
    NEDD8 activating enzyme activity GO:0019781 ISO
    small protein activating enzyme activity GO:0008641 IEA
    ligand-dependent nuclear receptor binding GO:0016922 IPI
    protein heterodimerization activity GO:0046982 ISO
    ATP binding GO:0005524 IEA
Biological Process
    endomitotic cell cycle GO:0007113 ISO
    mitotic cell cycle GO:0000278 ISO
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    regulation of cell cycle GO:0051726 ISO
    protein neddylation GO:0045116 TAS
Subcellular Localization
    nucleus GO:0005634 ISO
    cytosol GO:0005829 IBA
 Experiment description of studies that identified Uba3 in exosomes
Experiment ID 95
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Uba3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Uba3 is involved
No pathways found

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