Gene description for Slc4a7
Gene name solute carrier family 4, sodium bicarbonate cotransporter, member 7
Gene symbol Slc4a7
Other names/aliases NBC3
NBCn1
Species Rattus norvegicus
 Database cross references - Slc4a7
ExoCarta ExoCarta_117955
Vesiclepedia VP_117955
Entrez Gene 117955
UniProt Q9R1N3  
 Slc4a7 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Slc4a7
Molecular Function
    solute:inorganic anion antiporter activity GO:0005452 IEA
    protein binding GO:0005515 IPI
    monoatomic anion transmembrane transporter activity GO:0008509 IEA
    sodium:bicarbonate symporter activity GO:0008510 IBA
    sodium:bicarbonate symporter activity GO:0008510 IDA
    sodium:bicarbonate symporter activity GO:0008510 ISO
Biological Process
    purine nucleotide biosynthetic process GO:0006164 ISO
    pyrimidine nucleotide biosynthetic process GO:0006221 ISO
    visual perception GO:0007601 ISO
    sensory perception of sound GO:0007605 ISO
    inorganic anion transport GO:0015698 IEA
    bicarbonate transport GO:0015701 IBA
    bicarbonate transport GO:0015701 IEA
    cochlear nucleus development GO:0021747 ISO
    locomotory exploration behavior GO:0035641 ISO
    sodium ion transmembrane transport GO:0035725 IEA
    retinal cell programmed cell death GO:0046666 ISO
    regulation of intracellular pH GO:0051453 IBA
    regulation of intracellular pH GO:0051453 ISO
    transmembrane transport GO:0055085 IBA
    auditory receptor cell development GO:0060117 IBA
    auditory receptor cell development GO:0060117 ISO
    camera-type eye photoreceptor cell differentiation GO:0060219 ISO
    retina vasculature morphogenesis in camera-type eye GO:0061299 ISO
    cellular response to growth factor stimulus GO:0071363 ISO
    phagosome acidification GO:0090383 ISO
    monoatomic anion transmembrane transport GO:0098656 IEA
Subcellular Localization
    cytoplasm GO:0005737 ISO
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    membrane GO:0016020 ISO
    basolateral plasma membrane GO:0016323 IBA
    basolateral plasma membrane GO:0016323 IDA
    basolateral plasma membrane GO:0016323 IEA
    basolateral plasma membrane GO:0016323 ISO
    apical plasma membrane GO:0016324 IBA
    apical plasma membrane GO:0016324 IDA
    apical plasma membrane GO:0016324 ISO
    cytoplasmic vesicle GO:0031410 IDA
    stereocilium GO:0032420 IDA
 Experiment description of studies that identified Slc4a7 in sEVs
1
Experiment ID 94
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Slc4a7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Cftr  
Affinity Capture-Western Rattus norvegicus
View the network image/svg+xml



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