Gene description for Aqp1
Gene name aquaporin 1
Gene symbol Aqp1
Other names/aliases CHIP28
Species Mus musculus
 Database cross references - Aqp1
ExoCarta ExoCarta_11826
Entrez Gene 11826
UniProt Q02013  
 Aqp1 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Aqp1
Molecular Function
    glycerol channel activity GO:0015254 IBA
    transporter activity GO:0005215 IEA
    transmembrane transporter activity GO:0022857 ISO
    ammonium transmembrane transporter activity GO:0008519 ISO
    carbon dioxide transmembrane transporter activity GO:0035379 ISO
    intracellular cGMP activated cation channel activity GO:0005223 ISO
    nitric oxide transmembrane transporter activity GO:0030184 ISO
    glycerol transmembrane transporter activity GO:0015168 ISO
    ephrin receptor binding GO:0046875 IPI
    potassium ion transmembrane transporter activity GO:0015079 IDA
    potassium channel activity GO:0005267 ISO
    water transmembrane transporter activity GO:0005372 ISO
    water channel activity GO:0015250 TAS
Biological Process
    positive regulation of angiogenesis GO:0045766 ISO
    renal water absorption GO:0070295 IMP
    sensory perception of pain GO:0019233 IMP
    cellular response to cAMP GO:0071320 ISO
    carbon dioxide transport GO:0015670 ISO
    establishment or maintenance of actin cytoskeleton polarity GO:0030950 ISO
    response to drug GO:0042493 ISO
    corticotropin secretion GO:0051458 IMP
    secretory granule organization GO:0033363 IMP
    cellular response to copper ion GO:0071280 ISO
    cation transmembrane transport GO:0098655 ISO
    cellular homeostasis GO:0019725 ISO
    positive regulation of cell migration GO:0030335 IMP
    cellular water homeostasis GO:0009992 IBA
    cellular response to dexamethasone stimulus GO:0071549 ISO
    ammonium transport GO:0015696 ISO
    cellular response to hypoxia GO:0071456 ISO
    positive regulation of lamellipodium assembly GO:0010592 ISO
    positive regulation of fibroblast proliferation GO:0048146 ISO
    cellular response to UV GO:0034644 ISO
    potassium ion transport GO:0006813 IDA
    transmembrane transport GO:0055085 TAS
    cellular response to mechanical stimulus GO:0071260 ISO
    cellular response to retinoic acid GO:0071300 ISO
    lipid digestion GO:0044241 IMP
    positive regulation of epithelial cell migration GO:0010634 ISO
    water homeostasis GO:0030104 IMP
    cellular response to salt stress GO:0071472 ISO
    cellular response to stress GO:0033554 ISO
    positive regulation of saliva secretion GO:0046878 ISO
    water transport GO:0006833 TAS
    cellular hyperosmotic response GO:0071474 ISO
    carbohydrate transmembrane transport GO:0034219 IBA
    glomerular filtration GO:0003094 IMP
    negative regulation of apoptotic process GO:0043066 ISO
    nitric oxide transport GO:0030185 ISO
    potassium ion transmembrane transport GO:0071805 ISO
    cGMP biosynthetic process GO:0006182 ISO
    cellular response to inorganic substance GO:0071241 ISO
    cellular response to mercury ion GO:0071288 ISO
    maintenance of symbiont-containing vacuole by host GO:0085018 ISO
    transepithelial water transport GO:0035377 ISO
    wound healing GO:0042060 IMP
    renal water transport GO:0003097 ISO
    secretion by cell GO:0032940 IMP
    organic cation transport GO:0015695 IBA
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 ISO
    transport GO:0006810 IEA
    carbon dioxide transmembrane transport GO:0035378 ISO
    camera-type eye morphogenesis GO:0048593 IMP
    cellular response to hydrogen peroxide GO:0070301 ISO
    cell volume homeostasis GO:0006884 ISO
    glycerol transport GO:0015793 ISO
    cellular response to nitric oxide GO:0071732 ISO
    ammonium transmembrane transport GO:0072488 ISO
Subcellular Localization
    axon GO:0030424 IDA
    integral component of plasma membrane GO:0005887 TAS
    cytoplasm GO:0005737 ISO
    neuronal cell body membrane GO:0032809 ISO
    cell GO:0005623 IMP
    membrane GO:0016020 IDA
    integral component of membrane GO:0016021 IDA
    apical plasma membrane GO:0016324 ISO
    basolateral plasma membrane GO:0016323 ISO
    brush border membrane GO:0031526 ISO
    extracellular exosome GO:0070062 ISO
    plasma membrane GO:0005886 ISO
    apical part of cell GO:0045177 ISO
    brush border GO:0005903 ISO
    dense core granule membrane GO:0032127 ISO
    nucleus GO:0005634 ISO
    neuron projection GO:0043005 ISO
    sarcolemma GO:0042383 ISO
    basal plasma membrane GO:0009925 ISO
    axon terminus GO:0043679 ISO
    symbiont-containing vacuole GO:0020003 IDA
    symbiont-containing vacuole membrane GO:0020005 ISO
    nuclear membrane GO:0031965 ISO
 Experiment description of studies that identified Aqp1 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Aqp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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