Gene description for Aqp1
Gene name	aquaporin 1
Gene symbol	Aqp1
Other names/aliases	CHIP28
Species	Mus musculus
Database cross references - Aqp1
ExoCarta	ExoCarta_11826
Vesiclepedia	VP_11826
Entrez Gene	11826
UniProt	Q02013
Aqp1 identified in sEVs derived from the following tissue/cell type
Fibroblasts	23260141

Gene ontology annotations for Aqp1

Molecular Function     intracellularly cGMP-activated cation channel activity GO:0005223 ISO     intracellularly cGMP-activated cation channel activity GO:0005223 ISS     potassium channel activity GO:0005267 ISO     potassium channel activity GO:0005267 ISS     water transmembrane transporter activity GO:0005372 IDA     water transmembrane transporter activity GO:0005372 ISO     ammonium channel activity GO:0008519 IBA     ammonium channel activity GO:0008519 ISO     ammonium channel activity GO:0008519 ISS     potassium ion transmembrane transporter activity GO:0015079 IDA     glycerol transmembrane transporter activity GO:0015168 IBA     glycerol transmembrane transporter activity GO:0015168 ISO     glycerol transmembrane transporter activity GO:0015168 ISS     water channel activity GO:0015250 IBA     water channel activity GO:0015250 ISO     water channel activity GO:0015250 ISS     water channel activity GO:0015250 TAS     transmembrane transporter activity GO:0022857 ISO     nitric oxide transmembrane transporter activity GO:0030184 ISO     nitric oxide transmembrane transporter activity GO:0030184 ISS     carbon dioxide transmembrane transporter activity GO:0035379 IBA     carbon dioxide transmembrane transporter activity GO:0035379 ISO     carbon dioxide transmembrane transporter activity GO:0035379 ISS     identical protein binding GO:0042802 IEA     identical protein binding GO:0042802 ISO     ephrin receptor binding GO:0046875 IPI     hydrogen peroxide channel activity GO:0140070 IEA Biological Process     glomerular filtration GO:0003094 IMP     renal water transport GO:0003097 IBA     renal water transport GO:0003097 ISO     potassium ion transport GO:0006813 IDA     water transport GO:0006833 IDA     water transport GO:0006833 IGI     water transport GO:0006833 IMP     water transport GO:0006833 ISO     cell volume homeostasis GO:0006884 ISO     cell volume homeostasis GO:0006884 ISS     hyperosmotic response GO:0006972 IBA     intracellular water homeostasis GO:0009992 ISO     intracellular water homeostasis GO:0009992 ISS     positive regulation of lamellipodium assembly GO:0010592 IEA     positive regulation of lamellipodium assembly GO:0010592 ISO     positive regulation of epithelial cell migration GO:0010634 IEA     positive regulation of epithelial cell migration GO:0010634 ISO     fibroblast migration GO:0010761 IMP     positive regulation of fibroblast migration GO:0010763 IMP     carbon dioxide transport GO:0015670 ISO     carbon dioxide transport GO:0015670 ISS     glycerol transmembrane transport GO:0015793 ISO     glycerol transmembrane transport GO:0015793 ISS     cell migration GO:0016477 IMP     sensory perception of pain GO:0019233 IMP     cellular homeostasis GO:0019725 ISO     cellular homeostasis GO:0019725 ISS     cGMP-mediated signaling GO:0019934 ISO     cGMP-mediated signaling GO:0019934 ISS     lateral ventricle development GO:0021670 IEP     pancreatic juice secretion GO:0030157 IEA     nitric oxide transport GO:0030185 ISO     nitric oxide transport GO:0030185 ISS     establishment or maintenance of actin cytoskeleton polarity GO:0030950 ISO     establishment or maintenance of actin cytoskeleton polarity GO:0030950 ISS     secretion by cell GO:0032940 IMP     cerebrospinal fluid secretion GO:0033326 IEA     secretory granule organization GO:0033363 IMP     cellular response to UV GO:0034644 ISO     cellular response to UV GO:0034644 ISS     transepithelial water transport GO:0035377 ISO     transepithelial water transport GO:0035377 ISS     carbon dioxide transmembrane transport GO:0035378 IBA     carbon dioxide transmembrane transport GO:0035378 ISO     carbon dioxide transmembrane transport GO:0035378 ISS     wound healing GO:0042060 IMP     odontogenesis GO:0042476 IEA     negative regulation of apoptotic process GO:0043066 ISO     negative regulation of apoptotic process GO:0043066 ISS     response to estrogen GO:0043627 IEA     lipid digestion GO:0044241 IMP     positive regulation of angiogenesis GO:0045766 ISO     positive regulation of angiogenesis GO:0045766 ISS     positive regulation of saliva secretion GO:0046878 ISO     positive regulation of saliva secretion GO:0046878 ISS     positive regulation of fibroblast proliferation GO:0048146 ISO     positive regulation of fibroblast proliferation GO:0048146 ISS     camera-type eye morphogenesis GO:0048593 IMP     defense response to Gram-negative bacterium GO:0050829 IMP     defense response to Gram-negative bacterium GO:0050829 ISO     multicellular organismal-level water homeostasis GO:0050891 IMP     corticotropin secretion GO:0051458 IMP     establishment of localization in cell GO:0051649 IGI     establishment of localization in cell GO:0051649 IMP     renal water absorption GO:0070295 IGI     renal water absorption GO:0070295 IMP     cellular response to hydrogen peroxide GO:0070301 ISO     cellular response to hydrogen peroxide GO:0070301 ISS     cellular response to mechanical stimulus GO:0071260 ISO     cellular response to mechanical stimulus GO:0071260 ISS     cellular response to copper ion GO:0071280 ISO     cellular response to copper ion GO:0071280 ISS     cellular response to mercury ion GO:0071288 ISO     cellular response to mercury ion GO:0071288 ISS     cellular response to retinoic acid GO:0071300 ISO     cellular response to retinoic acid GO:0071300 ISS     cellular response to cAMP GO:0071320 ISO     cellular response to cAMP GO:0071320 ISS     cellular response to hypoxia GO:0071456 ISO     cellular response to hypoxia GO:0071456 ISS     cellular response to salt stress GO:0071472 ISO     cellular response to salt stress GO:0071472 ISS     cellular hyperosmotic response GO:0071474 ISO     cellular hyperosmotic response GO:0071474 ISS     cellular response to dexamethasone stimulus GO:0071549 ISO     cellular response to dexamethasone stimulus GO:0071549 ISS     cellular response to nitric oxide GO:0071732 IEA     cellular response to nitric oxide GO:0071732 ISO     potassium ion transmembrane transport GO:0071805 IEA     metanephric descending thin limb development GO:0072220 IEP     metanephric proximal straight tubule development GO:0072230 IEP     metanephric proximal convoluted tubule segment 2 development GO:0072232 IEP     metanephric glomerulus vasculature development GO:0072239 IEP     ammonium transmembrane transport GO:0072488 ISO     ammonium transmembrane transport GO:0072488 ISS     hydrogen peroxide transmembrane transport GO:0080170 IEA     negative regulation of cysteine-type endopeptidase activity GO:2000117 ISO Subcellular Localization     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISS     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 TAS     caveola GO:0005901 IDA     brush border GO:0005903 IDA     brush border GO:0005903 ISO     basal plasma membrane GO:0009925 IDA     basal plasma membrane GO:0009925 ISO     basal plasma membrane GO:0009925 ISS     membrane GO:0016020 IDA     basolateral plasma membrane GO:0016323 IDA     basolateral plasma membrane GO:0016323 ISO     apical plasma membrane GO:0016324 IDA     apical plasma membrane GO:0016324 ISO     axon GO:0030424 IDA     brush border membrane GO:0031526 ISO     brush border membrane GO:0031526 ISS     nuclear membrane GO:0031965 ISO     nuclear membrane GO:0031965 ISS     dense core granule membrane GO:0032127 ISO     neuronal cell body membrane GO:0032809 IEA     neuronal cell body membrane GO:0032809 ISO     sarcolemma GO:0042383 ISO     sarcolemma GO:0042383 ISS     axon terminus GO:0043679 IEA     axon terminus GO:0043679 ISO     apical part of cell GO:0045177 ISO     extracellular exosome GO:0070062 IDA     extracellular exosome GO:0070062 ISO     ankyrin-1 complex GO:0170014 ISO     ankyrin-1 complex GO:0170014 ISS