Gene description for Atp6v1e1
Gene name ATPase, H+ transporting, lysosomal V1 subunit E1
Gene symbol Atp6v1e1
Other names/aliases 2410029D23Rik
Atp6e
Atp6e2
Atp6v1e
D6Ertd385e
E2
P31
Vma4
Species Mus musculus
 Database cross references - Atp6v1e1
ExoCarta ExoCarta_11973
Entrez Gene 11973
UniProt P50518  
 Atp6v1e1 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
Pancreatic cells 19351151    
 Gene ontology annotations for Atp6v1e1
Molecular Function
    ATPase binding GO:0051117 ISO
    hydrogen-exporting ATPase activity, phosphorylative mechanism GO:0008553 IGI
    hydrolase activity GO:0016787 IEA
    proton-transporting ATPase activity, rotational mechanism GO:0046961 IEA
    protein binding GO:0005515 IPI
Biological Process
    ATP hydrolysis coupled proton transport GO:0015991 IGI
    proton transport GO:0015992 IEA
    ion transport GO:0006811 IEA
    transport GO:0006810 IEA
Subcellular Localization
    apical plasma membrane GO:0016324 IDA
    mitochondrion GO:0005739 IDA
    extracellular exosome GO:0070062 ISO
    proton-transporting two-sector ATPase complex, catalytic domain GO:0033178 IEA
    endosome GO:0005768 IDA
    lysosomal membrane GO:0005765 ISO
    microvillus GO:0005902 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified Atp6v1e1 in exosomes
1
Experiment ID 210
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD81|FLOT1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Atp6v1e1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Atp6v1e1 is involved
PathwayEvidenceSource
Insulin receptor recycling IEA Reactome
Ion channel transport IEA Reactome
Transferrin endocytosis and recycling IEA Reactome





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