Gene description for Atp6v1e1
Gene name ATPase, H+ transporting, lysosomal V1 subunit E1
Gene symbol Atp6v1e1
Other names/aliases 2410029D23Rik
Atp6e
Atp6e2
Atp6v1e
D6Ertd385e
E2
P31
Vma4
Species Mus musculus
 Database cross references - Atp6v1e1
ExoCarta ExoCarta_11973
Vesiclepedia VP_11973
Entrez Gene 11973
UniProt P50518  
 Atp6v1e1 identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
Pancreatic cells 19351151    
 Gene ontology annotations for Atp6v1e1
Molecular Function
    protein binding GO:0005515 IPI
    proton-transporting ATPase activity, rotational mechanism GO:0046961 IBA
    proton-transporting ATPase activity, rotational mechanism GO:0046961 IGI
    ATPase binding GO:0051117 IEA
    ATPase binding GO:0051117 ISO
Biological Process
    synaptic vesicle lumen acidification GO:0097401 EXP
    synaptic vesicle lumen acidification GO:0097401 IDA
    synaptic vesicle lumen acidification GO:0097401 IMP
    proton transmembrane transport GO:1902600 IGI
Subcellular Localization
    vacuolar proton-transporting V-type ATPase, V1 domain GO:0000221 ISO
    vacuolar proton-transporting V-type ATPase, V1 domain GO:0000221 ISS
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 HDA
    endosome GO:0005768 IDA
    cytosol GO:0005829 IDA
    microvillus GO:0005902 IDA
    apical plasma membrane GO:0016324 IDA
    clathrin-coated vesicle membrane GO:0030665 IEA
    synaptic vesicle membrane GO:0030672 IEA
    extrinsic component of synaptic vesicle membrane GO:0098850 ISO
 Experiment description of studies that identified Atp6v1e1 in sEVs
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 188
MISEV standards
EM
Biophysical techniques
GAPDH|UCHL1|HSP90
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Atp6v1e1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tfe3  
Affinity Capture-MS Mus musculus
2 Atxn1  
Affinity Capture-MS Mus musculus
3 Kctd13  
Affinity Capture-MS Mus musculus
4 Mapt  
Affinity Capture-MS Mus musculus
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