Gene description for Atp8a1
Gene name ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
Gene symbol Atp8a1
Other names/aliases AI481521
AI853962
APLT
AW743152
AW822227
Atp3a2
B230107D19Rik
ClassI
Species Mus musculus
 Database cross references - Atp8a1
ExoCarta ExoCarta_11980
Entrez Gene 11980
UniProt P70704  
 Atp8a1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Atp8a1
Molecular Function
    metal ion binding GO:0046872 IEA
    phospholipid-translocating ATPase activity GO:0004012 IBA
    nucleotide binding GO:0000166 IEA
    ATP binding GO:0005524 IEA
    protein binding GO:0005515 IPI
    hydrolase activity GO:0016787 IEA
    magnesium ion binding GO:0000287 IEA
Biological Process
    positive regulation of cell migration GO:0030335 IMP
    transport GO:0006810 IEA
    phospholipid transport GO:0015914 IEA
    phospholipid translocation GO:0045332 IBA
    positive regulation of phospholipid translocation GO:0061092 IDA
    lipid transport GO:0006869 IEA
    learning GO:0007612 IMP
Subcellular Localization
    plasma membrane GO:0005886 ISO
    integral component of membrane GO:0016021 IEA
    membrane GO:0016020 ISO
    Golgi apparatus GO:0005794 ISO
    extracellular exosome GO:0070062 ISO
    cytoplasmic vesicle GO:0031410 IEA
    endoplasmic reticulum GO:0005783 ISO
 Experiment description of studies that identified Atp8a1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Atp8a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Atp8a1 is involved
PathwayEvidenceSource
Ion transport by P-type ATPases IEA Reactome





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