Gene description for Cspg4
Gene name chondroitin sulfate proteoglycan 4
Gene symbol Cspg4
Other names/aliases 4732461B14Rik
Species Mus musculus
 Database cross references - Cspg4
ExoCarta ExoCarta_121021
Entrez Gene 121021
UniProt Q8VHY0  
 Cspg4 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Cspg4
Molecular Function
    signal transducer activity GO:0004871 IEA
    collagen binding GO:0005518 ISO
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 ISO
Biological Process
    neuron remodeling GO:0016322 ISO
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO
    intracellular signal transduction GO:0035556 ISO
    inflammatory response GO:0006954 ISO
    negative regulation of neuron projection development GO:0010977 ISO
    cell differentiation GO:0030154 IEA
    angiogenesis GO:0001525 IEA
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IMP
    multicellular organismal development GO:0007275 IEA
    signal transduction GO:0007165 IEA
    activation of MAPK activity GO:0000187 IMP
    cell proliferation GO:0008283 IMP
    glial cell migration GO:0008347 IDA
    tissue remodeling GO:0048771 IEA
Subcellular Localization
    cell projection GO:0042995 IDA
    focal adhesion GO:0005925 ISO
    integral component of membrane GO:0016021 IEA
    membrane GO:0016020 IEA
    intracellular GO:0005622 ISO
    plasma membrane GO:0005886 ISO
    extracellular exosome GO:0070062 ISO
    cell surface GO:0009986 ISO
 Experiment description of studies that identified Cspg4 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Cspg4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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