Gene description for Birc6
Gene name baculoviral IAP repeat-containing 6
Gene symbol Birc6
Other names/aliases A430032G04Rik
A430040A19Rik
AA501170
Bruce
D630005A10Rik
mKIAA1289
Species Mus musculus
 Database cross references - Birc6
ExoCarta ExoCarta_12211
Entrez Gene 12211
UniProt O88738  
 Birc6 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Birc6
Molecular Function
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity GO:0008766 IEA
    coenzyme F420-2 alpha-glutamyl ligase activity GO:0043774 IEA
    protein-glutamic acid ligase activity GO:0070739 IEA
    ribosomal S6-glutamic acid ligase activity GO:0018169 IEA
    ubiquitin-protein transferase activity GO:0004842 ISO
    protein-glycine ligase activity, elongating GO:0070737 IEA
    tubulin-glutamic acid ligase activity GO:0070740 IEA
    protein-glycine ligase activity GO:0070735 IEA
    ligase activity GO:0016874 IEA
    cysteine-type endopeptidase inhibitor activity GO:0004869 ISO
    tubulin-glycine ligase activity GO:0070738 IEA
    protein-glycine ligase activity, initiating GO:0070736 IEA
    peptidase inhibitor activity GO:0030414 IEA
    coenzyme F420-0 gamma-glutamyl ligase activity GO:0043773 IEA
    ubiquitin conjugating enzyme activity GO:0061631 IDA
    protein binding GO:0005515 IPI
Biological Process
    regulation of signal transduction GO:0009966 IBA
    negative regulation of endopeptidase activity GO:0010951 ISO
    positive regulation of cell proliferation GO:0008284 IMP
    regulation of cell proliferation GO:0042127 IMP
    mitotic nuclear division GO:0007067 IEA
    cell division GO:0051301 IEA
    labyrinthine layer development GO:0060711 IMP
    spongiotrophoblast layer development GO:0060712 IMP
    cell cycle GO:0007049 IEA
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 ISO
    negative regulation of peptidase activity GO:0010466 IEA
    placenta development GO:0001890 IMP
    regulation of cytokinesis GO:0032465 ISO
    apoptotic process GO:0006915 IEA
    negative regulation of apoptotic process GO:0043066 ISO
    protein ubiquitination GO:0016567 IDA
Subcellular Localization
    membrane GO:0016020 ISO
    spindle pole GO:0000922 ISO
    cytoplasm GO:0005737 IBA
    midbody GO:0030496 ISO
    microtubule organizing center GO:0005815 ISO
    cytoskeleton GO:0005856 IEA
    trans-Golgi network GO:0005802 ISO
    Golgi apparatus GO:0005794 IEA
    endosome GO:0005768 ISO
 Experiment description of studies that identified Birc6 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Birc6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Birc6 is involved
No pathways found





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