Gene description for TDRD9
Gene name tudor domain containing 9
Gene symbol TDRD9
Other names/aliases C14orf75
HIG-1
NET54
Species Homo sapiens
 Database cross references - TDRD9
ExoCarta ExoCarta_122402
Entrez Gene 122402
HGNC 20122
UniProt Q8NDG6  
 TDRD9 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TDRD9
Molecular Function
    ATP binding GO:0005524 IEA
    poly(A) RNA binding GO:0044822 IBA
    ATP-dependent RNA helicase activity GO:0004004 IBA
Biological Process
    cell differentiation GO:0030154 IEA
    male meiosis GO:0007140 ISS
    multicellular organismal development GO:0007275 IEA
    piRNA metabolic process GO:0034587 TAS
    fertilization GO:0009566 ISS
    spermatogenesis GO:0007283 ISS
    RNA processing GO:0006396 IBA
    gene silencing by RNA GO:0031047 IEA
    gene expression GO:0010467 TAS
    DNA methylation involved in gamete generation GO:0043046 ISS
Subcellular Localization
    P granule GO:0043186 IBA
    cytoplasm GO:0005737 IBA
    piP-body GO:0071547 ISS
    nucleus GO:0005634 ISS
 Experiment description of studies that identified TDRD9 in exosomes
1
Experiment ID 235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for TDRD9
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TDRD9 is involved
PathwayEvidenceSource
PIWI-interacting RNA (piRNA) biogenesis TAS Reactome





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