Gene description for Cab39
Gene name calcium binding protein 39
Gene symbol Cab39
Other names/aliases AA408805
AA960512
C78372
MO25
MO25alpha
Species Mus musculus
 Database cross references - Cab39
ExoCarta ExoCarta_12283
Vesiclepedia VP_12283
Entrez Gene 12283
UniProt Q06138  
 Cab39 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cab39
Molecular Function
    protein kinase activator activity GO:0030295 ISO
    calcium ion binding GO:0005509 ISS
    protein serine/threonine kinase activator activity GO:0043539 ISO
    kinase binding GO:0019900 ISO
Biological Process
    intracellular signal transduction GO:0035556 ISO
    signal transduction by protein phosphorylation GO:0023014 ISO
    positive regulation of peptidyl-serine phosphorylation GO:0033138 ISO
    positive regulation of peptidyl-threonine phosphorylation GO:0010800 ISO
    positive regulation of protein serine/threonine kinase activity GO:0071902 ISO
    activation of protein kinase activity GO:0032147 IDA
Subcellular Localization
    cytoplasm GO:0005737 IC
    intracellular GO:0005622 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Cab39 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cab39
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cab39 is involved
PathwayEvidenceSource
Regulation of AMPK activity via LKB1 IEA Reactome





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