Gene description for Cacna2d1
Gene name calcium channel, voltage-dependent, alpha2/delta subunit 1
Gene symbol Cacna2d1
Other names/aliases Ca(v)alpha2delta1
Cacna2
Cchl2a
Species Mus musculus
 Database cross references - Cacna2d1
ExoCarta ExoCarta_12293
Vesiclepedia VP_12293
Entrez Gene 12293
UniProt O08532  
 Cacna2d1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cacna2d1
Molecular Function
    calcium channel regulator activity GO:0005246 IBA
    voltage-gated calcium channel activity GO:0005245 ISO
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
    voltage-gated ion channel activity GO:0005244 IEA
    calcium channel activity GO:0005262 IEA
Biological Process
    regulation of calcium ion transport GO:0051924 ISO
    ion transport GO:0006811 IEA
    calcium ion transport GO:0006816 ISO
    regulation of ion transmembrane transport GO:0034765 ISO
    calcium ion transmembrane transport GO:0070588 ISO
    transport GO:0006810 IEA
Subcellular Localization
    membrane GO:0016020 IEA
    T-tubule GO:0030315 IDA
    sarcoplasmic reticulum GO:0016529 IDA
    integral component of membrane GO:0016021 IEA
    voltage-gated calcium channel complex GO:0005891 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Cacna2d1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cacna2d1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cacna2d1 is involved
No pathways found





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