Gene description for Cacna2d1
Gene name calcium channel, voltage-dependent, alpha2/delta subunit 1
Gene symbol Cacna2d1
Other names/aliases Ca(v)alpha2delta1
Cacna2
Cchl2a
Species Mus musculus
 Database cross references - Cacna2d1
ExoCarta ExoCarta_12293
Vesiclepedia VP_12293
Entrez Gene 12293
UniProt O08532  
 Cacna2d1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cacna2d1
Molecular Function
    voltage-gated calcium channel activity GO:0005245 IBA
    voltage-gated calcium channel activity GO:0005245 ISO
    voltage-gated calcium channel activity GO:0005245 ISO
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    voltage-gated calcium channel activity involved in bundle of His cell action potential GO:0086057 IEA
    voltage-gated calcium channel activity involved in bundle of His cell action potential GO:0086057 ISO
Biological Process
    calcium ion transport GO:0006816 ISO
    regulation of calcium ion transport GO:0051924 IMP
    regulation of calcium ion transport GO:0051924 ISO
    regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 ISO
    regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 ISS
    calcium ion transport into cytosol GO:0060402 ISO
    calcium ion transport into cytosol GO:0060402 ISS
    calcium ion transmembrane transport via high voltage-gated calcium channel GO:0061577 ISO
    calcium ion transmembrane transport via high voltage-gated calcium channel GO:0061577 ISS
    calcium ion transmembrane transport GO:0070588 ISO
    calcium ion transmembrane transport GO:0070588 ISS
    cardiac muscle cell action potential involved in contraction GO:0086002 ISO
    cardiac muscle cell action potential involved in contraction GO:0086002 ISS
    membrane depolarization during bundle of His cell action potential GO:0086048 IEA
    membrane depolarization during bundle of His cell action potential GO:0086048 ISO
    regulation of heart rate by cardiac conduction GO:0086091 ISO
    regulation of heart rate by cardiac conduction GO:0086091 ISS
    regulation of membrane repolarization during action potential GO:0098903 ISO
    regulation of membrane repolarization during action potential GO:0098903 ISS
    regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1902514 IEA
    regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1902514 ISO
    cellular response to amyloid-beta GO:1904646 IEA
    cellular response to amyloid-beta GO:1904646 ISO
Subcellular Localization
    plasma membrane GO:0005886 ISO
    voltage-gated calcium channel complex GO:0005891 IMP
    voltage-gated calcium channel complex GO:0005891 ISO
    sarcoplasmic reticulum GO:0016529 IDA
    T-tubule GO:0030315 IDA
    postsynaptic membrane GO:0045211 ISO
    presynaptic active zone membrane GO:0048787 IDA
    presynaptic active zone membrane GO:0048787 IMP
    presynaptic active zone membrane GO:0048787 ISO
    glutamatergic synapse GO:0098978 ISO
    GABA-ergic synapse GO:0098982 IDA
    GABA-ergic synapse GO:0098982 IMP
    neuronal dense core vesicle GO:0098992 EXP
    neuronal dense core vesicle GO:0098992 IDA
    L-type voltage-gated calcium channel complex GO:1990454 IBA
    L-type voltage-gated calcium channel complex GO:1990454 ISO
    L-type voltage-gated calcium channel complex GO:1990454 ISS
 Experiment description of studies that identified Cacna2d1 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cacna2d1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tnik  
Affinity Capture-MS Mus musculus
2 Cacna1c  
Co-fractionation Mus musculus
3 Cacnb2  
Co-fractionation Mus musculus
4 Kctd13  
Affinity Capture-MS Mus musculus
5 Cacna2d4  
Co-fractionation Mus musculus
6 Htt  
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
7 Ryr1  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Cacna2d1 is involved
No pathways found





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