Gene description for Capg
Gene name capping protein (actin filament), gelsolin-like
Gene symbol Capg
Other names/aliases gCap39
mbh1
Species Mus musculus
 Database cross references - Capg
ExoCarta ExoCarta_12332
Entrez Gene 12332
 Capg identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
Microglia 16081791    
 Gene ontology annotations for Capg
Molecular Function
    actin binding GO:0003779 IEA
    protein domain specific binding GO:0019904 ISO
    protein complex binding GO:0032403 ISO
Biological Process
    actin filament capping GO:0051693 IEA
    cell projection assembly GO:0030031 IDA
    barbed-end actin filament capping GO:0051016 IEA
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleolus GO:0005730 ISO
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    extracellular region GO:0005576 IEA
    mitotic spindle GO:0072686 ISO
    centriole GO:0005814 ISO
    extracellular exosome GO:0070062 ISO
    Flemming body GO:0090543 ISO
 Experiment description of studies that identified Capg in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
2
Experiment ID 14
ISEV standards
EM
EV Biophysical techniques
RAB7|RAB11
EV Cytosolic markers
CD9|CD63|LAMP1|LAMP2
EV Membrane markers
DNM
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 16081791    
Organism Mus musculus
Experiment description Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism.
Authors Potolicchio I, Carven GJ, Xu X, Stipp C, Riese RJ, Stern LJ, Santambrogio L
Journal name JIMMU
Publication year 2005
Sample Microglia
Sample name N9
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
 Protein-protein interactions for Capg
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Capg is involved
No pathways found





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