Gene description for Car2
Gene name carbonic anhydrase 2
Gene symbol Car2
Other names/aliases AI131712
CAII
Ca2
Car-2
Ltw-5
Lvtw-5
Species Mus musculus
 Database cross references - Car2
ExoCarta ExoCarta_12349
Entrez Gene 12349
UniProt P00920  
 Car2 identified in exosomes derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Car2
Molecular Function
    zinc ion binding GO:0008270 ISO
    arylesterase activity GO:0004064 ISO
    metal ion binding GO:0046872 IEA
    lyase activity GO:0016829 IEA
    carbonate dehydratase activity GO:0004089 ISO
Biological Process
    angiotensin-activated signaling pathway GO:0038166 ISO
    positive regulation of cellular pH reduction GO:0032849 ISO
    regulation of anion transport GO:0044070 ISO
    secretion GO:0046903 IMP
    positive regulation of bone resorption GO:0045780 ISO
    regulation of pH GO:0006885 IC
    regulation of chloride transport GO:2001225 IMP
    morphogenesis of an epithelium GO:0002009 IMP
    carbon dioxide transport GO:0015670 IMP
    positive regulation of dipeptide transmembrane transport GO:2001150 IMP
    positive regulation of synaptic transmission, GABAergic GO:0032230 IGI
    regulation of intracellular pH GO:0051453 IMP
    one-carbon metabolic process GO:0006730 IEA
    positive regulation of osteoclast differentiation GO:0045672 ISO
Subcellular Localization
    basolateral plasma membrane GO:0016323 ISO
    apical part of cell GO:0045177 ISO
    myelin sheath GO:0043209 IDA
    extracellular exosome GO:0070062 ISO
    cell GO:0005623 IMP
    axon GO:0030424 ISO
    plasma membrane GO:0005886 ISO
    cytosol GO:0005829 IDA
    cytoplasm GO:0005737 ISO
    extracellular space GO:0005615 ISO
    membrane GO:0016020 IEA
    microvillus GO:0005902 ISO
 Experiment description of studies that identified Car2 in exosomes
1
Experiment ID 33
ISEV standards
EM|IEM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Car2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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