Gene description for Casp8
Gene name	caspase 8
Gene symbol	Casp8
Other names/aliases	CASP-8 FLICE MACH Mch5
Species	Mus musculus
Database cross references - Casp8
ExoCarta	ExoCarta_12370
Entrez Gene	12370
UniProt	O89110
Casp8 identified in exosomes derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Casp8

Molecular Function     cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097199 ISO     cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 ISO     cysteine-type endopeptidase activity GO:0004197 ISO     endopeptidase activity GO:0004175 IMP     scaffold protein binding GO:0097110 ISO     hydrolase activity GO:0016787 IEA     protein heterodimerization activity GO:0046982 IPI     cysteine-type peptidase activity GO:0008234 IEA     ubiquitin protein ligase binding GO:0031625 ISO     protein binding GO:0005515 IPI     tumor necrosis factor receptor binding GO:0005164 ISO     death receptor binding GO:0005123 ISO     protein complex binding GO:0032403 ISO     death effector domain binding GO:0035877 ISO     peptidase activity GO:0008233 ISO Biological Process     positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 ISO     extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IMP     extrinsic apoptotic signaling pathway GO:0097191 ISO     angiogenesis GO:0001525 IMP     neural tube formation GO:0001841 IMP     response to ethanol GO:0045471 ISO     proteolysis involved in cellular protein catabolic process GO:0051603 ISO     negative regulation of necroptotic process GO:0060546 IGI     macrophage differentiation GO:0030225 TAS     proteolysis GO:0006508 ISO     regulation of apoptotic process GO:0042981 IEA     cardiac muscle tissue development GO:0048738 TAS     regulation of apoptotic signaling pathway GO:2001233 IGI     positive regulation of macrophage differentiation GO:0045651 ISO     activation of cysteine-type endopeptidase activity GO:0097202 ISO     apoptotic process GO:0006915 ISO     negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 ISO     TRAIL-activated apoptotic signaling pathway GO:0036462 ISO     positive regulation of proteolysis GO:0045862 ISO     apoptotic signaling pathway GO:0097190 ISO     hepatocyte apoptotic process GO:0097284 IMP     regulation of thymocyte apoptotic process GO:0070243 IGI     heart development GO:0007507 IMP     positive regulation of extrinsic apoptotic signaling pathway GO:2001238 IGI     execution phase of apoptosis GO:0097194 ISO     protein heterooligomerization GO:0051291 ISO     response to tumor necrosis factor GO:0034612 ISO     activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 IDA Subcellular Localization     membrane raft GO:0045121 ISO     nucleus GO:0005634 IDA     CD95 death-inducing signaling complex GO:0031265 ISO     mitochondrion GO:0005739 ISO     Noc1p-Noc2p complex GO:0030690 IMP     nucleoplasm GO:0005654 ISO     neuron projection GO:0043005 ISO     cytoplasm GO:0005737 ISO     protein complex GO:0043234 ISO     cytosol GO:0005829 ISO     cell body GO:0044297 ISO     plasma membrane GO:0005886 IDA     microtubule organizing center GO:0005815 ISO     death-inducing signaling complex GO:0031264 ISO     ripoptosome GO:0097342 ISO