Gene description for Cd24a
Gene name CD24a antigen
Gene symbol Cd24a
Other names/aliases Cd24
HSA
Ly-52
nectadrin
Species Mus musculus
 Database cross references - Cd24a
ExoCarta ExoCarta_12484
Vesiclepedia VP_12484
Entrez Gene 12484
UniProt P24807  
 Cd24a identified in sEVs derived from the following tissue/cell type
Amniotic fluid 17700640    
Urine 17700640    
 Gene ontology annotations for Cd24a
Molecular Function
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 ISO
    protein kinase binding GO:0019901 ISS
    carbohydrate binding GO:0030246 IDA
    protein tyrosine kinase activator activity GO:0030296 IBA
    protein tyrosine kinase activator activity GO:0030296 ISO
    protein tyrosine kinase activator activity GO:0030296 ISS
    Hsp70 protein binding GO:0030544 IDA
    Hsp90 protein binding GO:0051879 IDA
Biological Process
    response to hypoxia GO:0001666 ISS
    cell activation GO:0001775 IBA
    cell activation GO:0001775 ISO
    cell activation GO:0001775 ISS
    T cell homeostatic proliferation GO:0001777 IMP
    B cell apoptotic process GO:0001783 IDA
    regulation of cytokine-mediated signaling pathway GO:0001959 IMP
    response to molecule of bacterial origin GO:0002237 IDA
    pre-B cell differentiation GO:0002329 IMP
    leukocyte migration involved in inflammatory response GO:0002523 IMP
    positive regulation of T cell mediated immune response to tumor cell GO:0002842 IDA
    positive regulation of inflammatory response to antigenic stimulus GO:0002863 IMP
    positive regulation of B cell apoptotic process GO:0002904 IDA
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IDA
    leukocyte cell-cell adhesion GO:0007159 IDA
    cell surface receptor signaling pathway GO:0007166 IDA
    positive regulation of cytosolic calcium ion concentration GO:0007204 ISO
    positive regulation of cytosolic calcium ion concentration GO:0007204 ISS
    neuromuscular synaptic transmission GO:0007274 IGI
    neuromuscular synaptic transmission GO:0007274 IMP
    neuroblast proliferation GO:0007405 IMP
    negative regulation of neuroblast proliferation GO:0007406 IMP
    apoptotic mitochondrial changes GO:0008637 IDA
    positive regulation of neuron projection development GO:0010976 IDA
    positive regulation of neuron projection development GO:0010976 IGI
    cell migration GO:0016477 IMP
    peptidyl-tyrosine phosphorylation GO:0018108 IDA
    calcium-mediated signaling GO:0019722 IDA
    regulation of cell-cell adhesion GO:0022407 IBA
    regulation of cell-cell adhesion GO:0022407 IDA
    positive regulation of cell-cell adhesion GO:0022409 IDA
    apoptotic nuclear changes GO:0030262 IDA
    negative regulation of B cell proliferation GO:0030889 IDA
    neuron projection development GO:0031175 IDA
    neuron projection development GO:0031175 IDA
    neuron projection development GO:0031175 IGI
    neuron projection development GO:0031175 IMP
    T cell costimulation GO:0031295 ISO
    T cell costimulation GO:0031295 ISS
    B cell receptor transport into membrane raft GO:0032597 ISO
    B cell receptor transport into membrane raft GO:0032597 ISS
    chemokine receptor transport out of membrane raft GO:0032600 IMP
    negative regulation of interleukin-6 production GO:0032715 IMP
    negative regulation of tumor necrosis factor production GO:0032720 IMP
    negative regulation of transforming growth factor beta3 production GO:0032913 ISO
    negative regulation of transforming growth factor beta3 production GO:0032913 ISS
    integrin activation GO:0033622 IDA
    integrin activation GO:0033622 IMP
    positive regulation of integrin activation GO:0033625 IDA
    positive regulation of integrin activation GO:0033625 IMP
    positive regulation of cell adhesion mediated by integrin GO:0033630 IDA
    positive regulation of cell adhesion mediated by integrin GO:0033630 IMP
    regulation of cell-cell adhesion mediated by integrin GO:0033632 IDA
    positive regulation of cell-cell adhesion mediated by integrin GO:0033634 IDA
    negative regulation of erythrocyte clearance GO:0034107 IMP
    homotypic cell-cell adhesion GO:0034109 IMP
    negative regulation of erythrocyte aggregation GO:0034119 IMP
    CD4-positive, alpha-beta T cell proliferation GO:0035739 IDA
    CD4-positive, alpha-beta T cell proliferation GO:0035739 IMP
    B cell proliferation GO:0042100 IDA
    positive regulation of T cell homeostatic proliferation GO:0042103 IMP
    positive regulation of activated T cell proliferation GO:0042104 ISO
    positive regulation of activated T cell proliferation GO:0042104 ISS
    regulation of phosphorylation GO:0042325 ISO
    regulation of phosphorylation GO:0042325 ISS
    cholesterol homeostasis GO:0042632 IMP
    positive regulation of MAP kinase activity GO:0043406 ISO
    positive regulation of MAP kinase activity GO:0043406 ISS
    regulation of MAPK cascade GO:0043408 ISO
    regulation of MAPK cascade GO:0043408 ISS
    response to estrogen GO:0043627 ISS
    innate immune response GO:0045087 IEA
    regulation of B cell differentiation GO:0045577 IMP
    negative regulation of neuron differentiation GO:0045665 IMP
    respiratory burst GO:0045730 ISO
    respiratory burst GO:0045730 ISS
    negative regulation of T cell homeostatic proliferation GO:0046014 IMP
    positive regulation of alpha-beta T cell proliferation GO:0046641 IDA
    positive regulation of alpha-beta T cell proliferation GO:0046641 IMP
    synaptic vesicle endocytosis GO:0048488 IMP
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA
    negative regulation of neurogenesis GO:0050768 IMP
    positive regulation of calcium-mediated signaling GO:0050850 IDA
    negative regulation of monocyte chemotactic protein-1 production GO:0071638 IMP
    podocyte differentiation GO:0072112 ISO
    podocyte differentiation GO:0072112 ISS
    glomerular parietal epithelial cell differentiation GO:0072139 ISO
    glomerular parietal epithelial cell differentiation GO:0072139 ISS
    apoptotic signaling pathway GO:0097190 IDA
    negative regulation of inflammatory response to wounding GO:0106015 IPI
    positive regulation of inflammatory response to wounding GO:0106016 IMP
    positive regulation of CD4-positive, alpha-beta T cell proliferation GO:2000563 IDA
    positive regulation of CD4-positive, alpha-beta T cell proliferation GO:2000563 IMP
    positive regulation of nephron tubule epithelial cell differentiation GO:2000768 ISO
    positive regulation of nephron tubule epithelial cell differentiation GO:2000768 ISS
Subcellular Localization
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IBA
    external side of plasma membrane GO:0009897 IDA
    external side of plasma membrane GO:0009897 ISO
    cell surface GO:0009986 IDA
    cell surface GO:0009986 ISO
    membrane GO:0016020 IDA
    membrane GO:0016020 ISO
    membrane GO:0016020 ISS
    motile cilium GO:0031514 IDA
    microvillus membrane GO:0031528 IDA
    intracellular membrane-bounded organelle GO:0043231 ISO
    membrane raft GO:0045121 IBA
    membrane raft GO:0045121 IDA
    membrane raft GO:0045121 ISO
    membrane raft GO:0045121 ISS
    ciliary membrane GO:0060170 IDA
    presynapse GO:0098793 IEA
 Experiment description of studies that identified Cd24a in sEVs
1
Experiment ID 59
MISEV standards
Biophysical techniques
CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 17700640    
Organism Mus musculus
Experiment description CD24 is a marker of exosomes secreted into urine and amniotic fluid.
Authors "Keller S, Rupp C, Stoeck A, Runz S, Fogel M, Lugert S, Hager HD, Abdel-Bakky MS, Gutwein P, Altevogt P"
Journal name KI
Publication year 2007
Sample Amniotic fluid
Sample name Amniotic fluid
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
2
Experiment ID 60
MISEV standards
Biophysical techniques
CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 17700640    
Organism Mus musculus
Experiment description CD24 is a marker of exosomes secreted into urine and amniotic fluid.
Authors "Keller S, Rupp C, Stoeck A, Runz S, Fogel M, Lugert S, Hager HD, Abdel-Bakky MS, Gutwein P, Altevogt P"
Journal name KI
Publication year 2007
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
 Protein-protein interactions for Cd24a
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cd24a is involved
No pathways found





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