Gene description for Cd34
Gene name CD34 antigen
Gene symbol Cd34
Other names/aliases AU040960
Species Mus musculus
 Database cross references - Cd34
ExoCarta ExoCarta_12490
Vesiclepedia VP_12490
Entrez Gene 12490
UniProt Q64314  
 Cd34 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cd34
Molecular Function
    transcription factor binding GO:0008134 ISO
    sulfate binding GO:0043199 IDA
    carbohydrate binding GO:0030246 ISO
Biological Process
    cell adhesion GO:0007155 IEA
    negative regulation of neuron death GO:1901215 ISO
    negative regulation of cellular response to hypoxia GO:1900038 ISO
    positive regulation of glial cell line-derived neurotrophic factor secretion GO:1900168 ISO
    negative regulation of cellular response to heat GO:1900035 ISO
    hematopoietic stem cell proliferation GO:0071425 ISO
    positive regulation of transforming growth factor beta production GO:0071636 ISO
    negative regulation of blood coagulation GO:0030195 ISO
    regulation of blood pressure GO:0008217 ISO
    negative regulation of tumor necrosis factor production GO:0032720 ISO
    negative regulation of nitric oxide biosynthetic process GO:0045019 ISO
    paracrine signaling GO:0038001 ISO
    positive regulation of interleukin-10 production GO:0032733 ISO
    tissue homeostasis GO:0001894 ISO
    single organismal cell-cell adhesion GO:0016337 ISO
    extracellular exosome assembly GO:0071971 ISO
    hemopoiesis GO:0030097 ISO
    positive regulation of angiogenesis GO:0045766 ISO
    leukocyte migration GO:0050900 IMP
    positive regulation of vasculogenesis GO:2001214 ISO
    positive regulation of odontogenesis GO:0042482 ISO
    endothelial cell proliferation GO:0001935 ISO
    positive regulation of granulocyte colony-stimulating factor production GO:0071657 ISO
    negative regulation of gene expression GO:0010629 ISO
    negative regulation of interleukin-2 secretion GO:1900041 ISO
Subcellular Localization
    plasma membrane GO:0005886 ISO
    extracellular region GO:0005576 IDA
    external side of plasma membrane GO:0009897 ISO
    lysosome GO:0005764 ISO
    apical plasma membrane GO:0016324 ISO
    cell surface GO:0009986 IDA
    glomerular endothelium fenestra GO:0036053 ISO
    intercellular bridge GO:0045171 ISO
    integral component of membrane GO:0016021 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
    cell periphery GO:0071944 IDA
    membrane GO:0016020 IDA
    cytoplasm GO:0005737 ISO
    basal plasma membrane GO:0009925 ISO
 Experiment description of studies that identified Cd34 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cd34
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cd34 is involved
PathwayEvidenceSource
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here