Gene description for Cd34
Gene name CD34 antigen
Gene symbol Cd34
Other names/aliases AU040960
Species Mus musculus
 Database cross references - Cd34
ExoCarta ExoCarta_12490
Vesiclepedia VP_12490
Entrez Gene 12490
UniProt Q64314  
 Cd34 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cd34
Molecular Function
    carbohydrate binding GO:0030246 ISO
    carbohydrate binding GO:0030246 ISS
    sulfate binding GO:0043199 IDA
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IEA
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 ISO
Biological Process
    tissue homeostasis GO:0001894 ISO
    tissue homeostasis GO:0001894 ISS
    endothelial cell proliferation GO:0001935 IEA
    endothelial cell proliferation GO:0001935 ISO
    glomerular filtration GO:0003094 ISS
    cell-matrix adhesion GO:0007160 IBA
    signal transduction GO:0007165 IEA
    negative regulation of gene expression GO:0010629 ISO
    hemopoiesis GO:0030097 ISO
    negative regulation of interleukin-2 production GO:0032703 IEA
    negative regulation of interleukin-2 production GO:0032703 ISO
    mesangial cell-matrix adhesion GO:0035759 ISS
    paracrine signaling GO:0038001 IEA
    paracrine signaling GO:0038001 ISO
    positive regulation of odontogenesis GO:0042482 ISO
    positive regulation of odontogenesis GO:0042482 ISS
    positive regulation of angiogenesis GO:0045766 ISO
    positive regulation of angiogenesis GO:0045766 ISS
    leukocyte migration GO:0050900 IMP
    transdifferentiation GO:0060290 IEA
    vascular wound healing GO:0061042 IEA
    hematopoietic stem cell proliferation GO:0071425 IEA
    hematopoietic stem cell proliferation GO:0071425 ISO
    positive regulation of granulocyte colony-stimulating factor production GO:0071657 IEA
    positive regulation of granulocyte colony-stimulating factor production GO:0071657 ISO
    extracellular exosome assembly GO:0071971 IEA
    extracellular exosome assembly GO:0071971 ISO
    glomerular endothelium development GO:0072011 IEA
    metanephric glomerular mesangial cell differentiation GO:0072254 IEA
    cell-cell adhesion GO:0098609 ISO
    cell-cell adhesion GO:0098609 ISS
    positive regulation of vasculogenesis GO:2001214 ISO
    positive regulation of vasculogenesis GO:2001214 ISS
Subcellular Localization
    extracellular region GO:0005576 IDA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    lysosome GO:0005764 ISO
    lysosome GO:0005764 ISS
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    external side of plasma membrane GO:0009897 IDA
    external side of plasma membrane GO:0009897 ISO
    basal plasma membrane GO:0009925 ISO
    basal plasma membrane GO:0009925 ISS
    cell surface GO:0009986 IDA
    membrane GO:0016020 IDA
    apical plasma membrane GO:0016324 ISO
    apical plasma membrane GO:0016324 ISS
    glomerular endothelium fenestra GO:0036053 ISO
    glomerular endothelium fenestra GO:0036053 ISS
    intercellular bridge GO:0045171 ISO
    intercellular bridge GO:0045171 ISS
    perinuclear region of cytoplasm GO:0048471 ISO
    perinuclear region of cytoplasm GO:0048471 ISS
    cell periphery GO:0071944 IDA
 Experiment description of studies that identified Cd34 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cd34
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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