Gene description for Cd38
Gene name CD38 antigen
Gene symbol Cd38
Other names/aliases ADPRC 1
Cd38-rs1
Species Mus musculus
 Database cross references - Cd38
ExoCarta ExoCarta_12494
Vesiclepedia VP_12494
Entrez Gene 12494
UniProt P56528  
 Cd38 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cd38
Molecular Function
    phosphorus-oxygen lyase activity GO:0016849 IMP
    NAD+ nucleosidase activity GO:0003953 ISO
    hydrolase activity, acting on glycosyl bonds GO:0016798 IMP
    hydrolase activity GO:0016787 IEA
    NAD(P)+ nucleosidase activity GO:0050135 IEA
    transferase activity GO:0016740 IEA
Biological Process
    B cell receptor signaling pathway GO:0050853 ISO
    negative regulation of transcription, DNA-templated GO:0045892 ISO
    positive regulation of cell growth GO:0030307 ISO
    response to hormone GO:0009725 ISO
    metabolic process GO:0008152 ISO
    negative regulation of apoptotic process GO:0043066 ISO
    positive regulation of transcription, DNA-templated GO:0045893 ISO
    response to drug GO:0042493 ISO
    negative regulation of bone resorption GO:0045779 ISO
    positive regulation of insulin secretion GO:0032024 ISO
    response to hypoxia GO:0001666 ISO
    positive regulation of vasoconstriction GO:0045907 ISO
    positive regulation of B cell proliferation GO:0030890 ISO
    positive regulation of cytosolic calcium ion concentration GO:0007204 ISO
    response to hydroperoxide GO:0033194 ISO
    long term synaptic depression GO:0060292 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    extracellular exosome GO:0070062 ISO
    cytosol GO:0005829 ISO
    integral component of membrane GO:0016021 IEA
    cell surface GO:0009986 IDA
    plasma membrane GO:0005886 ISO
    membrane GO:0016020 IDA
 Experiment description of studies that identified Cd38 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cd38
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cd38 is involved
No pathways found





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