Gene description for Entpd2
Gene name ectonucleoside triphosphate diphosphohydrolase 2
Gene symbol Entpd2
Other names/aliases Cd39l1
Species Mus musculus
 Database cross references - Entpd2
ExoCarta ExoCarta_12496
Entrez Gene 12496
UniProt O55026  
 Entpd2 identified in exosomes derived from the following tissue/cell type
Mov neuroglial cells 15210972    
 Gene ontology annotations for Entpd2
Molecular Function
    UDP-2,3-diacylglucosamine hydrolase activity GO:0008758 IEA
    ATP-dependent 5'-3' DNA helicase activity GO:0043141 IEA
    hydrolase activity GO:0016787 IEA
    ATPase activity GO:0016887 ISO
    pyrophosphatase activity GO:0016462 IEA
    dITP diphosphatase activity GO:0035870 IEA
    adenosine-diphosphatase activity GO:0043262 ISO
    dihydroneopterin monophosphate phosphatase activity GO:0019176 IEA
    identical protein binding GO:0042802 ISO
    bis(5'-nucleosyl)-tetraphosphatase activity GO:0008796 IEA
    8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity GO:0008413 IEA
    nucleoside-diphosphatase activity GO:0017110 IDA
    nucleoside-triphosphatase activity GO:0017111 IDA
    dATP pyrophosphohydrolase activity GO:0008828 IEA
    dTTP diphosphatase activity GO:0036218 IEA
    XTP diphosphatase activity GO:0036222 IEA
    nucleotide binding GO:0000166 IEA
    protein binding GO:0005515 IPI
    dihydroneopterin triphosphate pyrophosphohydrolase activity GO:0019177 IEA
    thiamine-pyrophosphatase activity GO:0004787 IEA
    ATP binding GO:0005524 IEA
    phosphocholine hydrolase activity GO:0044606 IEA
Biological Process
    purine ribonucleoside diphosphate catabolic process GO:0009181 IDA
    platelet activation GO:0030168 IDA
    metabolic process GO:0008152 ISO
    G-protein coupled receptor signaling pathway GO:0007186 IDA
    protein homooligomerization GO:0051260 ISO
    cellular response to interleukin-6 GO:0071354 ISO
Subcellular Localization
    basal lamina GO:0005605 IDA
    cell surface GO:0009986 ISO
    cell projection membrane GO:0031253 ISO
    integral component of membrane GO:0016021 IEA
    cell body GO:0044297 ISO
    extracellular exosome GO:0070062 ISO
    membrane GO:0016020 IEA
    plasma membrane GO:0005886 ISO
 Experiment description of studies that identified Entpd2 in exosomes
Experiment ID 39
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15210972    
Organism Mus musculus
Experiment description Cells release prions in association with exosomes.
Authors Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G
Journal name PNAS
Publication year 2004
Sample Mov neuroglial cells
Sample name Mov neuroglial cell
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Entpd2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Entpd2 is involved
No pathways found

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