Gene description for SPNS2
Gene name spinster homolog 2 (Drosophila)
Gene symbol SPNS2
Other names/aliases -
Species Homo sapiens
 Database cross references - SPNS2
ExoCarta ExoCarta_124976
Vesiclepedia VP_124976
Entrez Gene 124976
HGNC 26992
MIM 612584
UniProt Q8IVW8  
 SPNS2 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SPNS2
Molecular Function
    sphingolipid transporter activity GO:0046624 IBA
Biological Process
    sphingolipid metabolic process GO:0006665 IEA
    regulation of humoral immune response GO:0002920 IEA
    lipid transport GO:0006869 IEA
    transmembrane transport GO:0055085 IEA
    regulation of eye pigmentation GO:0048073 IEA
    bone development GO:0060348 IEA
    lymph node development GO:0048535 IEA
    sphingosine-1-phosphate signaling pathway GO:0003376 IBA
    lymphocyte migration GO:0072676 IEA
    locomotion GO:0040011 IBA
    T cell homeostasis GO:0043029 IEA
    B cell homeostasis GO:0001782 IEA
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    vesicle GO:0031982 IBA
    lysosomal membrane GO:0005765 IBA
 Experiment description of studies that identified SPNS2 in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SPNS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SPNS2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here