Gene description for Cd44
Gene name CD44 antigen
Gene symbol Cd44
Other names/aliases AU023126
AW121933
AW146109
HERMES
Ly-24
Pgp-1
Species Mus musculus
 Database cross references - Cd44
ExoCarta ExoCarta_12505
Entrez Gene 12505
UniProt P15379  
 Cd44 identified in exosomes derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Cd44
Molecular Function
    cytokine receptor activity GO:0004896 ISO
    hyalurononglucosaminidase activity GO:0004415 ISO
    hyaluronic acid binding GO:0005540 ISO
    epidermal growth factor receptor binding GO:0005154 ISO
    phosphoprotein binding GO:0051219 ISO
    protein kinase binding GO:0019901 ISO
    protein binding GO:0005515 IPI
    cytokine binding GO:0019955 IDA
Biological Process
    cell adhesion GO:0007155 ISO
    branching involved in ureteric bud morphogenesis GO:0001658 IMP
    neuron projection development GO:0031175 ISO
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 ISO
    positive regulation of gene expression GO:0010628 IGI
    negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 ISO
    positive regulation of neutrophil apoptotic process GO:0033031 ISO
    Wnt signaling pathway GO:0016055 IDA
    hyaluronan catabolic process GO:0030214 ISO
    cell migration GO:0016477 ISO
    negative regulation of apoptotic process GO:0043066 ISO
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 ISO
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO
    monocyte aggregation GO:0070487 ISO
    positive regulation of adaptive immune response GO:0002821 NAS
    macrophage fusion GO:0034238 ISO
    wound healing involved in inflammatory response GO:0002246 IMP
    positive regulation of monocyte aggregation GO:1900625 ISO
    positive regulation of heterotypic cell-cell adhesion GO:0034116 ISO
    positive regulation of peptidyl-serine phosphorylation GO:0033138 ISO
    negative regulation of mature B cell apoptotic process GO:0002906 IDA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO
    regulation of cell growth GO:0001558 ISO
    cellular response to fibroblast growth factor stimulus GO:0044344 ISO
    branching involved in prostate gland morphogenesis GO:0060442 IMP
Subcellular Localization
    protein complex GO:0043234 ISO
    plasma membrane GO:0005886 ISO
    external side of plasma membrane GO:0009897 IDA
    macrophage migration inhibitory factor receptor complex GO:0035692 ISO
    nucleus GO:0005634 ISO
    integral component of membrane GO:0016021 IEA
    cytoplasm GO:0005737 ISO
    cell surface GO:0009986 ISO
    membrane GO:0016020 IEA
    focal adhesion GO:0005925 ISO
    apical plasma membrane GO:0016324 ISO
    Golgi apparatus GO:0005794 ISO
    basolateral plasma membrane GO:0016323 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Cd44 in exosomes
1
Experiment ID 214
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Cd44
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cd44 is involved
No pathways found





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