Gene description for Cd59a
Gene name CD59a antigen
Gene symbol Cd59a
Other names/aliases AA987121
Cd59
protectin
Species Mus musculus
 Database cross references - Cd59a
ExoCarta ExoCarta_12509
Vesiclepedia VP_12509
Entrez Gene 12509
UniProt O55186  
 Cd59a identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Cd59a
Molecular Function
    complement binding GO:0001848 IBA
    complement binding GO:0001848 ISO
Biological Process
    negative regulation of activation of membrane attack complex GO:0001971 IBA
    negative regulation of activation of membrane attack complex GO:0001971 IDA
    negative regulation of activation of membrane attack complex GO:0001971 IMP
    negative regulation of activation of membrane attack complex GO:0001971 ISO
    negative regulation of angiogenesis GO:0016525 IMP
    regulation of complement activation GO:0030449 ISO
    negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948 IMP
    positive regulation of T cell proliferation GO:0042102 ISO
    negative regulation of apoptotic process GO:0043066 ISO
    negative regulation of complement activation GO:0045916 IDA
    negative regulation of fibroblast growth factor production GO:0090272 IDA
    regulation of complement-dependent cytotoxicity GO:1903659 ISO
    negative regulation of complement-dependent cytotoxicity GO:1903660 ISO
Subcellular Localization
    extracellular space GO:0005615 ISO
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    external side of plasma membrane GO:0009897 IDA
    cell surface GO:0009986 IDA
    cell surface GO:0009986 ISO
    sarcolemma GO:0042383 ISO
    compact myelin GO:0043218 ISO
 Experiment description of studies that identified Cd59a in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Cd59a
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cd59a is involved
No pathways found





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