Gene description for Cd59a
Gene name CD59a antigen
Gene symbol Cd59a
Other names/aliases AA987121
Cd59
protectin
Species Mus musculus
 Database cross references - Cd59a
ExoCarta ExoCarta_12509
Entrez Gene 12509
UniProt O55186  
 Cd59a identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Cd59a
Molecular Function
    complement binding GO:0001848 IBA
Biological Process
    negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948 IMP
    negative regulation of activation of membrane attack complex GO:0001971 IMP
    negative regulation of angiogenesis GO:0016525 IMP
    negative regulation of complement activation GO:0045916 IDA
    cell surface receptor signaling pathway GO:0007166 IBA
    negative regulation of fibroblast growth factor production GO:0090272 IDA
Subcellular Localization
    cell surface GO:0009986 IBA
    anchored component of membrane GO:0031225 IEA
    membrane GO:0016020 IEA
    external side of plasma membrane GO:0009897 IDA
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified Cd59a in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Cd59a
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cd59a is involved
PathwayEvidenceSource
Regulation of Complement cascade IEA Reactome





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