Gene description for Cd86
Gene name CD86 antigen
Gene symbol Cd86
Other names/aliases B7
B7-2
B7.2
B70
CLS1
Cd28l2
ETC-1
Ly-58
Ly58
MB7
MB7-2
TS/A-2
Species Mus musculus
 Database cross references - Cd86
ExoCarta ExoCarta_12524
Entrez Gene 12524
UniProt P42082  
 Cd86 identified in exosomes derived from the following tissue/cell type
Mast cells 11145662    
Mast cells 11306949    
 Gene ontology annotations for Cd86
Molecular Function
    receptor binding GO:0005102 ISO
Biological Process
    positive regulation of activated T cell proliferation GO:0042104 ISO
    cellular response to lipopolysaccharide GO:0071222 IDA
    immune system process GO:0002376 IEA
    positive regulation of T cell proliferation GO:0042102 ISO
    negative regulation of T cell anergy GO:0002668 ISO
    defense response to virus GO:0051607 IDA
    toll-like receptor signaling pathway GO:0002224 IDA
    B cell activation GO:0042113 IDA
Subcellular Localization
    membrane GO:0016020 IEA
    external side of plasma membrane GO:0009897 IDA
    extracellular exosome GO:0070062 ISO
    intracellular membrane-bounded organelle GO:0043231 IDA
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 IEA
    cell surface GO:0009986 ISO
 Experiment description of studies that identified Cd86 in exosomes
1
Experiment ID 5
ISEV standards
✔
EM|IEM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD86|CD80
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method ELISA
PubMed ID 11145662    
Organism Mus musculus
Experiment description Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes.
Authors Skokos D, Le Panse S, Villa I, Rousselle JC, Peronet R, David B, Namane A, Mecheri S
Journal name JIMMU
Publication year 2001
Sample Mast cells
Sample name P815
MC9
Bone marrow-derived mast cells
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
ELISA
2
Experiment ID 6
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 11306949    
Organism Mus musculus
Experiment description Nonspecific B and T cell-stimulatory activity mediated by mast cells is associated with exosomes.
Authors Skokos D, Le Panse S, Villa I, Rousselle JC, Peronet R, Namane A, David B, Mecheri S
Journal name IAAI
Publication year 2001
Sample Mast cells
Sample name Bone marrow-derived mast cells
Isolation/purification methods -
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
 Protein-protein interactions for Cd86
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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