Gene description for Cdk5
Gene name cyclin-dependent kinase 5
Gene symbol Cdk5
Other names/aliases AW048668
Crk6
Species Mus musculus
 Database cross references - Cdk5
ExoCarta ExoCarta_12568
Vesiclepedia VP_12568
Entrez Gene 12568
UniProt P49615  
 Cdk5 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cdk5
Molecular Function
    p53 binding GO:0002039 IPI
    protein kinase activity GO:0004672 IDA
    protein kinase activity GO:0004672 IMP
    protein kinase activity GO:0004672 ISO
    protein serine/threonine kinase activity GO:0004674 IDA
    protein serine/threonine kinase activity GO:0004674 ISO
    protein serine/threonine kinase activity GO:0004674 ISS
    protein serine/threonine kinase activity GO:0004674 TAS
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    cyclin-dependent protein serine/threonine kinase activity GO:0004693 IBA
    cyclin-dependent protein serine/threonine kinase activity GO:0004693 ISO
    cyclin-dependent protein serine/threonine kinase activity GO:0004693 ISS
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    ErbB-2 class receptor binding GO:0005176 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    cytoskeletal protein binding GO:0008092 ISO
    kinase activity GO:0016301 ISO
    kinase activity GO:0016301 ISS
    protein kinase binding GO:0019901 ISO
    acetylcholine receptor activator activity GO:0030549 IDA
    histone kinase activity GO:0035173 ISO
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    ErbB-3 class receptor binding GO:0043125 IDA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    ephrin receptor binding GO:0046875 ISO
    tau-protein kinase activity GO:0050321 ISO
    tau-protein kinase activity GO:0050321 ISS
    Hsp90 protein binding GO:0051879 IPI
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    neuron migration GO:0001764 IMP
    positive regulation of protein phosphorylation GO:0001934 ISO
    synaptic transmission, dopaminergic GO:0001963 IMP
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 IDA
    protein phosphorylation GO:0006468 IGI
    protein phosphorylation GO:0006468 IMP
    protein phosphorylation GO:0006468 ISO
    intracellular protein transport GO:0006886 IMP
    exocytosis GO:0006887 ISO
    nucleocytoplasmic transport GO:0006913 ISO
    apoptotic process GO:0006915 IDA
    DNA damage response GO:0006974 ISO
    mitochondrion organization GO:0007005 ISO
    cell-matrix adhesion GO:0007160 IDA
    axonogenesis GO:0007409 IBA
    axonogenesis GO:0007409 IMP
    synapse assembly GO:0007416 IMP
    skeletal muscle tissue development GO:0007519 IDA
    motor neuron axon guidance GO:0008045 IMP
    associative learning GO:0008306 IMP
    visual learning GO:0008542 IMP
    Schwann cell development GO:0014044 IMP
    phosphorylation GO:0016310 ISO
    cell migration GO:0016477 IDA
    cell migration GO:0016477 IMP
    peptidyl-serine phosphorylation GO:0018105 IDA
    peptidyl-serine phosphorylation GO:0018105 IMP
    peptidyl-serine phosphorylation GO:0018105 IMP
    peptidyl-serine phosphorylation GO:0018105 ISO
    peptidyl-threonine phosphorylation GO:0018107 IDA
    peptidyl-threonine phosphorylation GO:0018107 IMP
    sensory perception of pain GO:0019233 IMP
    telencephalon development GO:0021537 IMP
    cerebellum development GO:0021549 IMP
    cerebellar cortex development GO:0021695 IMP
    cerebellar cortex formation GO:0021697 IMP
    hippocampus development GO:0021766 IMP
    layer formation in cerebral cortex GO:0021819 IMP
    central nervous system neuron development GO:0021954 IMP
    cerebral cortex development GO:0021987 IMP
    corpus callosum development GO:0022038 IMP
    neuron differentiation GO:0030182 IMP
    neuron differentiation GO:0030182 ISA
    neuron differentiation GO:0030182 ISO
    neuron differentiation GO:0030182 ISS
    regulation of cell migration GO:0030334 IMP
    negative regulation of axon extension GO:0030517 IGI
    cortical actin cytoskeleton organization GO:0030866 ISO
    forebrain development GO:0030900 IMP
    neuron projection development GO:0031175 ISO
    neuron projection development GO:0031175 ISS
    negative regulation of protein ubiquitination GO:0031397 IMP
    negative regulation of synaptic plasticity GO:0031914 IMP
    positive regulation of protein binding GO:0032092 IMP
    receptor catabolic process GO:0032801 IMP
    positive regulation of glial cell apoptotic process GO:0034352 ISO
    synaptic transmission, glutamatergic GO:0035249 IMP
    protein localization to synapse GO:0035418 IMP
    response to cocaine GO:0042220 IMP
    serine phosphorylation of STAT protein GO:0042501 IDA
    receptor clustering GO:0043113 IMP
    positive regulation of neuron apoptotic process GO:0043525 ISO
    positive regulation of neuron apoptotic process GO:0043525 ISS
    regulated exocytosis GO:0045055 ISO
    negative regulation of cell cycle GO:0045786 IMP
    positive regulation of protein kinase activity GO:0045860 IMP
    negative regulation of proteolysis GO:0045861 IEA
    negative regulation of proteolysis GO:0045861 ISO
    negative regulation of DNA-templated transcription GO:0045892 IEA
    negative regulation of DNA-templated transcription GO:0045892 ISO
    positive regulation of calcium ion-dependent exocytosis GO:0045956 IDA
    negative regulation of protein export from nucleus GO:0046826 IMP
    behavioral response to cocaine GO:0048148 IMP
    regulation of synaptic plasticity GO:0048167 ISO
    regulation of synaptic plasticity GO:0048167 ISS
    synaptic vesicle endocytosis GO:0048488 ISO
    synaptic vesicle transport GO:0048489 IBA
    rhythmic process GO:0048511 IEA
    oligodendrocyte differentiation GO:0048709 IEA
    oligodendrocyte differentiation GO:0048709 ISO
    neuron projection morphogenesis GO:0048812 ISO
    dendrite morphogenesis GO:0048813 IMP
    cell division GO:0051301 IEA
    neuron apoptotic process GO:0051402 IBA
    neuron apoptotic process GO:0051402 IMP
    neuron apoptotic process GO:0051402 ISO
    establishment of localization in cell GO:0051649 IMP
    regulation of synaptic transmission, glutamatergic GO:0051966 IMP
    regulation of postsynaptic membrane potential GO:0060078 IMP
    excitatory postsynaptic potential GO:0060079 IMP
    regulation of dendritic spine morphogenesis GO:0061001 IMP
    calcium ion import GO:0070509 IMP
    positive regulation of protein targeting to membrane GO:0090314 IMP
    regulation of presynaptic cytosolic calcium ion concentration GO:0099509 ISO
    positive regulation of presynaptic cytosolic calcium concentration GO:0099533 ISO
    regulation of cell cycle phase transition GO:1901987 IBA
    regulation of protein localization to plasma membrane GO:1903076 IMP
    cellular response to amyloid-beta GO:1904646 ISO
    regulation of synapse pruning GO:1905806 ISO
Subcellular Localization
    cyclin-dependent protein kinase holoenzyme complex GO:0000307 IEA
    cyclin-dependent protein kinase holoenzyme complex GO:0000307 ISO
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 ISO
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    microtubule GO:0005874 ISO
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    postsynaptic density GO:0014069 ISO
    postsynaptic density GO:0014069 ISS
    membrane GO:0016020 ISO
    membrane GO:0016020 ISS
    protein kinase 5 complex GO:0016533 IPI
    protein kinase 5 complex GO:0016533 ISO
    lamellipodium GO:0030027 IDA
    cell junction GO:0030054 ISO
    filopodium GO:0030175 IDA
    axon GO:0030424 IDA
    axon GO:0030424 ISO
    axon GO:0030424 ISS
    dendrite GO:0030425 ISO
    dendrite GO:0030425 ISS
    growth cone GO:0030426 ISO
    growth cone GO:0030426 ISS
    neuromuscular junction GO:0031594 ISO
    neuromuscular junction GO:0031594 ISO
    neuromuscular junction GO:0031594 ISS
    neuron projection GO:0043005 ISO
    neuronal cell body GO:0043025 ISO
    neuronal cell body GO:0043025 ISS
    perikaryon GO:0043204 IEA
    Schaffer collateral - CA1 synapse GO:0098685 ISO
    presynapse GO:0098793 ISO
    postsynapse GO:0098794 ISO
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Cdk5 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cdk5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Hist1h1a  
Biochemical Activity Mus musculus
2 HIST1H1A 3024
Biochemical Activity Homo sapiens
3 Tsc1  
Affinity Capture-MS Mus musculus
4 Cdk5r1  
Affinity Capture-Western Mus musculus
5 Stub1 56424
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
Biochemical Activity Mus musculus
Affinity Capture-Western Mus musculus
6 Kctd13  
Affinity Capture-MS Mus musculus
7 Dlg4  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
8 Ptpn2  
Co-fractionation Mus musculus
9 Mapt  
Affinity Capture-MS Mus musculus
10 Agap2  
Affinity Capture-MS Mus musculus
11 Pura 19290
Affinity Capture-Western Mus musculus
12 Lrrk2  
Affinity Capture-Western Mus musculus
13 Per2  
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
Biochemical Activity Mus musculus
14 Dlgap1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
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