Gene description for CNGB1
Gene name cyclic nucleotide gated channel beta 1
Gene symbol CNGB1
Other names/aliases CNCG2
CNCG3L
CNCG4
CNG4
CNGB1B
GAR1
GARP
GARP2
RCNC2
RCNCb
RCNCbeta
RP45
Species Homo sapiens
 Database cross references - CNGB1
ExoCarta ExoCarta_1258
Vesiclepedia VP_1258
Entrez Gene 1258
HGNC 2151
MIM 600724
UniProt Q14028  
 CNGB1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Prostate cancer cells 25844599    
 Gene ontology annotations for CNGB1
Molecular Function
    intracellularly cAMP-activated cation channel activity GO:0005222 IBA
    intracellularly cAMP-activated cation channel activity GO:0005222 IDA
    intracellularly cGMP-activated cation channel activity GO:0005223 IBA
    intracellularly cGMP-activated cation channel activity GO:0005223 IDA
    calcium channel activity GO:0005262 IEA
    sodium channel activity GO:0005272 IEA
    protein binding GO:0005515 IPI
    ligand-gated monoatomic ion channel activity GO:0015276 TAS
    cAMP binding GO:0030552 IDA
    cGMP binding GO:0030553 IBA
    cGMP binding GO:0030553 IDA
    protein-containing complex binding GO:0044877 IBA
Biological Process
    retina homeostasis GO:0001895 IBA
    retina homeostasis GO:0001895 IMP
    monoatomic cation transport GO:0006812 IDA
    potassium ion transport GO:0006813 ISS
    sodium ion transport GO:0006814 ISS
    calcium ion transport GO:0006816 ISS
    visual perception GO:0007601 ISS
    phototransduction GO:0007602 IEA
    sensory perception of smell GO:0007608 ISS
    positive regulation of gene expression GO:0010628 IEA
    olfactory nerve maturation GO:0021630 ISS
    protein localization to organelle GO:0033365 IEA
    sodium ion transmembrane transport GO:0035725 IEA
    photoreceptor cell outer segment organization GO:0035845 IEA
    photoreceptor cell maintenance GO:0045494 IEA
    detection of light stimulus involved in visual perception GO:0050908 IMP
    detection of chemical stimulus involved in sensory perception of smell GO:0050911 ISS
    regulation of cytosolic calcium ion concentration GO:0051480 IEA
    membrane depolarization GO:0051899 ISS
    calcium ion transmembrane transport GO:0070588 IEA
    monoatomic cation transmembrane transport GO:0098655 IBA
    ion channel modulating, G protein-coupled receptor signaling pathway GO:0099105 ISS
    response to odorant GO:1990834 ISS
Subcellular Localization
    photoreceptor outer segment GO:0001750 IBA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    intracellular cyclic nucleotide activated cation channel complex GO:0017071 IBA
    Golgi-associated vesicle membrane GO:0030660 TAS
    terminal bouton GO:0043195 IEA
    ciliary membrane GO:0060170 TAS
    non-motile cilium membrane GO:0098804 ISS
    rod photoreceptor outer segment GO:0120200 ISS
    transmembrane transporter complex GO:1902495 IDA
 Experiment description of studies that identified CNGB1 in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 274
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for CNGB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SRRM1 10250
Affinity Capture-MS Homo sapiens
2 ABCA4  
Affinity Capture-Western Homo sapiens
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