Gene description for CNGB1
Gene name cyclic nucleotide gated channel beta 1
Gene symbol CNGB1
Other names/aliases CNCG2
Species Homo sapiens
 Database cross references - CNGB1
ExoCarta ExoCarta_1258
Entrez Gene 1258
HGNC 2151
MIM 600724
UniProt Q14028  
 CNGB1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Prostate cancer cells 25844599    
 Gene ontology annotations for CNGB1
Molecular Function
    cGMP binding GO:0030553 IDA
    ligand-gated ion channel activity GO:0015276 TAS
    voltage-gated potassium channel activity GO:0005249 IBA
    protein binding GO:0005515 IPI
    intracellular cAMP activated cation channel activity GO:0005222 IBA
    intracellular cGMP activated cation channel activity GO:0005223 IDA
    cAMP binding GO:0030552 IEA
Biological Process
    visual perception GO:0007601 TAS
    regulation of rhodopsin mediated signaling pathway GO:0022400 TAS
    detection of light stimulus involved in visual perception GO:0050908 IMP
    protein localization to organelle GO:0033365 IEA
    organelle organization GO:0006996 TAS
    retina homeostasis GO:0001895 IMP
    cytosolic calcium ion homeostasis GO:0051480 IEA
    cation transport GO:0006812 IDA
    regulation of membrane potential GO:0042391 IBA
    transport GO:0006810 TAS
    rhodopsin mediated signaling pathway GO:0016056 TAS
    phototransduction, visible light GO:0007603 TAS
    sensory perception of smell GO:0007608 IEA
    potassium ion transmembrane transport GO:0071805 IBA
    protein heterotetramerization GO:0051290 IEA
    photoreceptor cell maintenance GO:0045494 IEA
Subcellular Localization
    intracellular cyclic nucleotide activated cation channel complex GO:0017071 IEA
    Golgi membrane GO:0000139 TAS
    integral component of plasma membrane GO:0005887 IBA
    ciliary membrane GO:0060170 TAS
    cytosol GO:0005829 IEA
    Golgi-associated vesicle membrane GO:0030660 TAS
    terminal bouton GO:0043195 IEA
    transmembrane transporter complex GO:1902495 IDA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified CNGB1 in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
Experiment ID 274
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for CNGB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ABCA4  
Affinity Capture-Western Homo sapiens
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