Gene description for CNGA1
Gene name cyclic nucleotide gated channel alpha 1
Gene symbol CNGA1
Other names/aliases CNCG
CNCG1
CNG-1
CNG1
RCNC1
RCNCa
RCNCalpha
RP49
Species Homo sapiens
 Database cross references - CNGA1
ExoCarta ExoCarta_1259
Vesiclepedia VP_1259
Entrez Gene 1259
HGNC 2148
MIM 123825
UniProt P29973  
 CNGA1 identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for CNGA1
Molecular Function
    intracellularly cAMP-activated cation channel activity GO:0005222 IBA
    intracellularly cAMP-activated cation channel activity GO:0005222 IDA
    intracellularly cGMP-activated cation channel activity GO:0005223 IBA
    intracellularly cGMP-activated cation channel activity GO:0005223 IDA
    calcium channel activity GO:0005262 IEA
    sodium channel activity GO:0005272 IEA
    protein binding GO:0005515 IPI
    cAMP binding GO:0030552 IDA
    cGMP binding GO:0030553 IBA
    cGMP binding GO:0030553 IDA
    protein-containing complex binding GO:0044877 IBA
Biological Process
    sodium ion transport GO:0006814 ISS
    calcium ion transport GO:0006816 ISS
    visual perception GO:0007601 IEA
    sodium ion transmembrane transport GO:0035725 IEA
    calcium ion transmembrane transport GO:0070588 IEA
    monoatomic cation transmembrane transport GO:0098655 IBA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    intracellular cyclic nucleotide activated cation channel complex GO:0017071 IBA
    photoreceptor outer segment membrane GO:0042622 IEA
    rod photoreceptor outer segment GO:0120200 ISS
 Experiment description of studies that identified CNGA1 in sEVs
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CNGA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NKX6-2  
Affinity Capture-MS Homo sapiens
2 SLC24A1  
Affinity Capture-Western Homo sapiens
3 C11orf31  
Affinity Capture-MS Homo sapiens
4 WWC1  
Affinity Capture-MS Homo sapiens
5 PNMA2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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