Gene description for Coro1a
Gene name coronin, actin binding protein 1A
Gene symbol Coro1a
Other names/aliases Clabp
Lmb3
TACO
p57
Species Mus musculus
 Database cross references - Coro1a
ExoCarta ExoCarta_12721
Vesiclepedia VP_12721
Entrez Gene 12721
UniProt O89053  
 Coro1a identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Mast cells 17486113    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Coro1a
Molecular Function
    actin binding GO:0003779 ISO
    actin monomer binding GO:0003785 IEA
    actin monomer binding GO:0003785 ISO
    protein binding GO:0005515 IPI
    cytoskeletal protein binding GO:0008092 IMP
    myosin heavy chain binding GO:0032036 IEA
    myosin heavy chain binding GO:0032036 ISO
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IEA
    protein homodimerization activity GO:0042803 ISO
    phosphatidylinositol 3-kinase binding GO:0043548 IEA
    phosphatidylinositol 3-kinase binding GO:0043548 ISO
    actin filament binding GO:0051015 IBA
    actin filament binding GO:0051015 IDA
    actin filament binding GO:0051015 ISO
Biological Process
    phagolysosome assembly GO:0001845 IEA
    phagolysosome assembly GO:0001845 ISO
    calcium ion transport GO:0006816 IMP
    vesicle fusion GO:0006906 IMP
    phagocytosis GO:0006909 ISO
    actin filament organization GO:0007015 IBA
    actin filament organization GO:0007015 IMP
    regulation of actin polymerization or depolymerization GO:0008064 IMP
    regulation of cell shape GO:0008360 IMP
    epithelial cell migration GO:0010631 IMP
    cell migration GO:0016477 IBA
    actin cytoskeleton organization GO:0030036 ISO
    leukocyte chemotaxis GO:0030595 IMP
    regulation of actin filament polymerization GO:0030833 IMP
    negative regulation of vesicle fusion GO:0031339 IMP
    cell-substrate adhesion GO:0031589 IEA
    cell-substrate adhesion GO:0031589 ISO
    uropod organization GO:0032796 IMP
    regulation of actin cytoskeleton organization GO:0032956 ISO
    response to cytokine GO:0034097 IMP
    nerve growth factor signaling pathway GO:0038180 IGI
    T cell proliferation GO:0042098 IMP
    positive regulation of T cell proliferation GO:0042102 IMP
    T cell activation GO:0042110 IMP
    T cell homeostasis GO:0043029 IMP
    natural killer cell degranulation GO:0043320 IEA
    natural killer cell degranulation GO:0043320 ISO
    negative regulation of neuron apoptotic process GO:0043524 IGI
    homeostasis of number of cells within a tissue GO:0048873 IMP
    positive regulation of T cell activation GO:0050870 IMP
    positive chemotaxis GO:0050918 IEA
    positive chemotaxis GO:0050918 ISO
    negative regulation of actin nucleation GO:0051126 IEA
    negative regulation of actin nucleation GO:0051126 ISO
    regulation of release of sequestered calcium ion into cytosol GO:0051279 IGI
    neuron apoptotic process GO:0051402 IGI
    establishment of localization in cell GO:0051649 IMP
    early endosome to recycling endosome transport GO:0061502 IMP
    cellular response to interleukin-4 GO:0071353 IDA
    T cell migration GO:0072678 IMP
    thymocyte migration GO:0072679 IMP
    positive regulation of T cell migration GO:2000406 IMP
Subcellular Localization
    immunological synapse GO:0001772 IDA
    immunological synapse GO:0001772 ISO
    phagocytic cup GO:0001891 IEA
    phagocytic cup GO:0001891 ISO
    cytoplasm GO:0005737 ISO
    early endosome GO:0005769 IDA
    actin filament GO:0005884 IEA
    actin filament GO:0005884 ISO
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    cell-cell junction GO:0005911 IDA
    actin cytoskeleton GO:0015629 IDA
    lamellipodium GO:0030027 IEA
    lamellipodium GO:0030027 ISO
    axon GO:0030424 IDA
    phagocytic vesicle membrane GO:0030670 IEA
    cortical actin cytoskeleton GO:0030864 IEA
    cortical actin cytoskeleton GO:0030864 ISO
    cortical actin cytoskeleton GO:0030864 ISO
    cell leading edge GO:0031252 IDA
    stereocilium tip GO:0032426 EXP
    protein-containing complex GO:0032991 IEA
    protein-containing complex GO:0032991 ISO
    synapse GO:0045202 IDA
    phagocytic vesicle GO:0045335 ISO
    glutamatergic synapse GO:0098978 IDA
 Experiment description of studies that identified Coro1a in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
3
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Coro1a
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tia1  
Affinity Capture-MS Mus musculus
2 Foxp3  
Affinity Capture-MS Mus musculus
3 Fancd2  
Affinity Capture-MS Mus musculus
4 Kctd13  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Coro1a is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here