Gene description for Coro1a
Gene name coronin, actin binding protein 1A
Gene symbol Coro1a
Other names/aliases Clabp
Lmb3
TACO
p57
Species Mus musculus
 Database cross references - Coro1a
ExoCarta ExoCarta_12721
Entrez Gene 12721
UniProt O89053  
 Coro1a identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Coro1a
Molecular Function
    cytoskeletal protein binding GO:0008092 IMP
    actin monomer binding GO:0003785 ISO
    phosphatidylinositol 3-kinase binding GO:0043548 ISO
    protein homodimerization activity GO:0042803 ISO
    identical protein binding GO:0042802 IGI
    actin filament binding GO:0051015 ISO
    actin binding GO:0003779 ISO
    protein C-terminus binding GO:0008022 ISO
    protein binding GO:0005515 IPI
    myosin heavy chain binding GO:0032036 ISO
    poly(A) RNA binding GO:0044822 ISO
Biological Process
    negative regulation of actin nucleation GO:0051126 ISO
    phagocytosis GO:0006909 ISO
    positive regulation of T cell proliferation GO:0042102 IMP
    homeostasis of number of cells within a tissue GO:0048873 IMP
    actin cytoskeleton organization GO:0030036 ISO
    calcium ion transport GO:0006816 IMP
    T cell homeostasis GO:0043029 IMP
    regulation of actin cytoskeleton organization GO:0032956 ISO
    nerve growth factor signaling pathway GO:0038180 IGI
    positive chemotaxis GO:0050918 ISO
    regulation of cell shape GO:0008360 IMP
    response to cytokine GO:0034097 IMP
    uropod organization GO:0032796 IMP
    regulation of actin polymerization or depolymerization GO:0008064 IMP
    regulation of release of sequestered calcium ion into cytosol GO:0051279 IGI
    natural killer cell degranulation GO:0043320 ISO
    actin filament organization GO:0007015 IMP
    regulation of actin filament polymerization GO:0030833 IMP
    early endosome to recycling endosome transport GO:0061502 IMP
    phagolysosome assembly GO:0001845 ISO
    cellular response to interleukin-4 GO:0071353 IDA
    negative regulation of neuron apoptotic process GO:0043524 IGI
    positive regulation of T cell activation GO:0050870 IMP
    cell migration GO:0016477 IMP
    leukocyte chemotaxis GO:0030595 IMP
    negative regulation of vesicle fusion GO:0031339 IMP
    positive regulation of cell migration GO:0030335 IMP
    cell-substrate adhesion GO:0031589 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    cell GO:0005623 IMP
    early endosome GO:0005769 IDA
    actin cytoskeleton GO:0015629 IDA
    cell-cell junction GO:0005911 IDA
    cytoskeleton GO:0005856 IEA
    axon GO:0030424 IDA
    cytoplasm GO:0005737 ISO
    lamellipodium GO:0030027 ISO
    cortical actin cytoskeleton GO:0030864 ISO
    protein complex GO:0043234 ISO
    phagocytic cup GO:0001891 ISO
    cell leading edge GO:0031252 IDA
    membrane GO:0016020 ISO
    actin filament GO:0005884 ISO
    cytoplasmic vesicle GO:0031410 IEA
    plasma membrane GO:0005886 ISO
    intracellular GO:0005622 IMP
    phagocytic vesicle GO:0045335 ISO
    immunological synapse GO:0001772 ISO
 Experiment description of studies that identified Coro1a in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Coro1a
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Coro1a is involved
No pathways found





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