Gene description for Col6a1
Gene name collagen, type VI, alpha 1
Gene symbol Col6a1
Other names/aliases AI747156
Col6a-1
Species Mus musculus
 Database cross references - Col6a1
ExoCarta ExoCarta_12833
Entrez Gene 12833
UniProt Q04857  
 Col6a1 identified in exosomes derived from the following tissue/cell type
Embryonic fibroblasts 18494037    
Fibroblasts 23260141    
 Gene ontology annotations for Col6a1
Molecular Function
    platelet-derived growth factor binding GO:0048407 ISO
Biological Process
    osteoblast differentiation GO:0001649 ISO
    protein heterotrimerization GO:0070208 ISO
    cellular response to amino acid stimulus GO:0071230 IDA
    cell adhesion GO:0007155 IEA
Subcellular Localization
    collagen trimer GO:0005581 IEA
    lysosomal membrane GO:0005765 ISO
    proteinaceous extracellular matrix GO:0005578 IDA
    membrane GO:0016020 ISO
    protein complex GO:0043234 ISO
    extracellular matrix GO:0031012 ISO
    extracellular exosome GO:0070062 ISO
    extracellular region GO:0005576 ISO
    sarcolemma GO:0042383 IDA
 Experiment description of studies that identified Col6a1 in exosomes
1
Experiment ID 73
ISEV standards
EM
EV Biophysical techniques
HSP70|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 18494037    
Organism Mus musculus
Experiment description Difference gel electrophoresis analysis of Ras-transformed fibroblast cell-derived exosomes.
Authors Ji H, Erfani N, Tauro BJ, Kapp EA, Zhu HJ, Moritz RL, Lim JW, Simpson RJ
Journal name ELEC
Publication year 2008
Sample Embryonic fibroblasts
Sample name NIH3T3
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA]
Western blotting
2
Experiment ID 210
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD81|FLOT1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Col6a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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